Serum organochlorines and breast cancer: a case-control study among African-American women
Serum organochlorines and breast cancer: a case-control study among African-American women
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DOI：
10.1007/s10552-006-0070-2
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发表时间：
2007-02-01
影响因子：
2.3
通讯作者：
Bernstein, Leslie
中科院分区：
文献类型：
--
作者：
Gatto, Nicole M.;Longnecker, Matthew P.;Bernstein, Leslie
这项以非裔美国妇女为基础的病例对照研究（355例乳腺癌病例患者，327例对照）研究了乳腺癌与多氯联苯和滴滴涕代谢物二氯二苯二氯乙烯（DDE）循环水平之间的关系。病例患者被诊断为浸润性乳腺癌，并在1995年6月至1998年7月之间进行了采访，对照组通过随机数字拨号方法确定。DDE和总PCBs的血清水平进行了调整，总脂质含量。采用多变量非条件Logistic回归方法估计比值比（OR）和95%置信区间（CI）。研究了肿瘤受体状态和癌症治疗的效应修饰。乳腺癌风险与血脂调整的PCB或DDE的五分位数增加无关（根据年龄、体重指数（BMI）和母乳喂养调整的DDE的最高与最低五分位数：OR = 1.02，95% CI =（0.61，1.72），p趋势= 0.74;对于多氯联苯：OR = 1.01，95% CI =（0.63，1.63），p趋势= 0.56）。BMI、母乳喂养、产次、绝经状态或肿瘤受体状态的分层风险无差异。这项研究是迄今为止对非洲裔美国妇女进行的最大规模的研究，并不支持DDE和总PCB在乳腺癌风险中的作用。
This population-based case-control study of African-American women (355 breast cancer case patients, 327 controls) examined the association between breast cancer and circulating levels of PCBs and dichlorodiphenyldichloroethene (DDE), a metabolite of DDT. Case patients were diagnosed with invasive breast carcinoma and interviewed between June 1995 and July 1998, and control subjects were identified by random digit dialing methods. Serum levels of DDE and total PCBs were adjusted for total lipid content. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable unconditional logistic regression methods. Effect modification by tumor receptor status and cancer treatment was investigated. Breast cancer risk was not associated with increasing quintiles of lipid-adjusted PCBs or DDE (highest versus lowest quintile adjusted for age, body mass index (BMI) and breastfeeding for DDE: OR = 1.02, 95% CI = (0.61, 1.72), p-trend = 0.74; for PCBs: OR = 1.01, 95% CI = (0.63, 1.63), p-trend = 0.56). Risk did not differ by strata of BMI, breastfeeding, parity, menopausal status or tumor receptor status. This study, the largest study of African-American women to date, does not support a role of DDE and total PCBs in breast cancer risk at the levels measured.