Interleukin-1α-899 (+4845) C→T polymorphism increases the risk of chronic periodontitis: Evidence from a meta-analysis of 23 case-control studies
Interleukin-1α-899 (+4845) C→T polymorphism increases the risk of chronic periodontitis: Evidence from a meta-analysis of 23 case-control studies
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DOI：
10.1016/j.gene.2013.09.043
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发表时间：
2013-12-10
期刊：
影响因子：
3.5
通讯作者：
Zhou, Juan
中科院分区：
文献类型：
--
作者：
Mao, Min;Zeng, Xian-Tao;Zhou, Juan
许多流行病学研究表明白细胞介素-1 α（IL-1 alpha）-899（+4845）C -> T多态性增加了慢性牙周炎（CP）的风险，而一些研究报告了相反的结果。因此，本荟萃分析的目的是研究IL-1 α-899（+4845）C -> T多态性与CP的关联。我们检索了PubMed数据库，截至2013年5月1日，最终获得了23项病例对照研究。数据提取后，我们使用Comprehensive Meta-Analysis v2.2软件进行荟萃分析。基于固定效应模型的总体结果显示IL-1 α-899（+4845）C -> T多态性与CP的风险增加显著相关：T与C的比值比（OR）= 1.29，95%可信区间（CI）= 1.15-1.44，p < 0.001）;TT与CC的OR = 1.59，95%CI = 1.22-2.07，p = 0.0005;（OR = 130，95% CI = 1.12-1.51，p = 0.0004），CT与CC;以及（CT-TT）与CC比较（OR = 1.40，95%CI = 1.21-1.61，p < 0.001）; TT与（CT+CC）比较（OR = 1.47，95%CI = 1.16-1.87，p = 0.002）。分层分析显示，高加索人和亚洲人的风险显著增加。结论：IL-1 α-899（+4845）C -> T多态性可能增加CP的发病风险。(C)2013爱思唯尔有限公司版权所有。
Many epidemiological studies have indicated that interleukin-1 alpha (IL-1 alpha) -899 (+4845) C -> T polymorphism increases the risk of chronic periodontitis (CP), whereas some studies have reported opposite results. Accordingly, the aim of this meta-analysis is to investigate the association of the IL-1 alpha -899 (+4845) C -> T polymorphism with CP. We searched the PubMed database up to May 1, 2013 and finally obtained 23 case-control studies. After data extraction, we performed meta-analysis using Comprehensive Meta-Analysis v2.2 software. The overall result based on the fixed-effect model showed that IL-1 alpha -899 (+4845) C -> T polymorphism was significantly associated with increased risk of CP: [odds ratio (OR) = 1.29,95% confidence interval (CI) = 1.15-1.44, p < 0.001] for T vs. C; (OR = 1.59, 95%CI = 1.22-2.07, p = 0.0005) for TT vs. CC; (OR = 130, 95% CI = 1.12-1.51, p = 0.0004) for CT vs. CC; and (OR = 1.40,95% CI = 1.21-1.61, p < 0.001) for (CT-TT) vs. CC; (OR = 1.47, 95% CI = 1.16-1.87, p = 0.002) for TT vs. (CT+CC). Stratified analyses revealed that there was a significantly increased risk for Caucasians and Asians. In conclusion, current evidence showed that IL-1 alpha -899 (+4845) C -> T polymorphism probably increased the risk of CP. (C) 2013 Elsevier B.V. All rights reserved.