Vascular endothelial growth factor and neovascularization in astrocytic tumors
Vascular endothelial growth factor and neovascularization in astrocytic tumors
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DOI：
10.1111/j.1440-1827.1998.tb03879.x
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发表时间：
1998-02-01
影响因子：
2.2
通讯作者：
Sawada, T
中科院分区：
文献类型：
--
作者：
Takekawa, Y;Sawada, T
血管结构是进行组织病理学诊断和评估恶性潜能的重要因素，特别是星形细胞肿瘤。血管内皮生长因子（vascular endothelial growth factor，VEGF）是肿瘤新生血管形成的调控因子，被认为受p53基因调控。应用St Anne-Mayo分级系统，对42例星形细胞肿瘤（1-4级）的VEGF分布与新生血管的关系进行了研究。应用免疫组化方法研究肿瘤细胞VEGF标记指数（LI）与p53蛋白标记指数（LI）的关系。在高恶性潜能肿瘤中，如3级和4级肿瘤的VEGF LI显著高于低恶性潜能肿瘤。在4级肿瘤中，VEGF LI与新生血管内皮细胞增殖指数之间存在显著相关性。p53 LI与VEGF LI、p53 LI与组织病理学分级无明显相关性。在星形细胞肿瘤中，VEGF的表达可能与肿瘤新生血管形成相关，并且可以被认为是星形细胞肿瘤恶性潜能的指标。
It has been widely recognized that the vascular structure is an important factor when making a histopathological diagnosis and assessing the malignancy potential, especially of astrocytic tumors. The vascular endothelial growth factor (VEGF), which is thought to be regulated by the p53 gene, is a regulation factor for tumor neovascularization. The relationship between VEGF distribution and neovasculature was studied in 42 cases of astrocytic tumors (grades 1-4), which were obtained from surgical material, and the St Anne-Mayo grading system was applied. The relationship between the labeling indices (LI) of VEGF and LI of p53 protein in tumor cells was also studied using immunohistochemistry. The VEGF LI in high-grade malignancy potential tumors, such as grade 3 and grade 4 tumors, was significantly higher than those that were low grade. In grade 4 tumors, a significant correlation between the VEGF LI and the proliferation indices of endothelial cells of neovasculatures was observed. No significant correlation was noted between p53 LI and VEGF LI, as well as p53 LI and histopathological grade. In astrocytic tumors, expression of VEGF may be correlated to tumor neovascularization, and can be considered as an indicator of malignancy potential in astrocytic tumors.