Observations on the occurrence of exacerbations in clinical course of systemic lupus erythematosus
Observations on the occurrence of exacerbations in clinical course of systemic lupus erythematosus
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DOI：
10.2152/jmi.55.112
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发表时间：
2008-02-01
影响因子：
0.7
通讯作者：
Sone, Saburo
中科院分区：
文献类型：
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作者：
Tomioka, Reiko;Tani, Kenji;Sone, Saburo
系统性红斑狼疮（SLE）是一种慢性疾病，其特征在于恶化和缓解的波动过程，并且长期预后的主要决定因素是伴随疾病活动性和治疗毒性的组织损伤引起的器官损伤。在这项研究中，我们评估了哪些SLE患者会发生急性加重，以及是否可以确定预测急性加重的因素。57例SLE患者（52例女性）纳入本研究。15例（26.3%）患者病情加重。一个相对增加的发病率恶化被发现在年轻的SLE患者。在SLE诊断时有狼疮性肾炎的患者比例增加，发现在随后的恶化的患者相比，在那些没有它的患者，观察到增加的发病率在WBC和血小板数量减少，C3和CH 50水平下降，并存在阳性的抗Sm抗体的患者在诊断时。提示年龄、肾损害、白细胞、血小板减少、补体抗Sm抗体水平降低是急性加重的预测因素。
Systemic lupus erythematosus (SLE) is a chronic disease that is characterized by an undulating course of exacerbations and remissions, and a major determinant of long-term prognosis is organ damage consequent to tissue injury that accompanies disease activity and toxicity of therapy. In this study, we evaluated which patients with SLE will develop an exacerbation and whether factors can be identified to predict the development of an exacerbation. Fifty-seven SLE patients (52 females) were included in this study. The exacerbation of SLE was found in 15 patients (26.3%). A relatively increased incidence of an exacerbation was found in younger SLE patients. An increased percentage of patients who had lupus nephritis at the time of diagnosis of SLE was found in patients with a subsequent exacerbation when compared with that in those without it. Increased incidence of an exacerbation was observed in patients who had decreased number of WBC and platelets, decreased level of C3 and CH50, and the presence positivity of anti-Sm antibodies at the time of the diagnosis. This study suggests that age, renal involvement, and the presence of decreased number of WBC and platelets, decreased level of complements anti-Sm antibodies are predictors of exacerbation.