Problems associated with biological markers of Alzheimer's disease
Problems associated with biological markers of Alzheimer's disease
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DOI：
10.1007/s11064-005-8827-7
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发表时间：
2005-12-01
影响因子：
4.4
通讯作者：
Pirttilä, T
中科院分区：
文献类型：
--
作者：
Frey, HJ;Mattila, KM;Pirttilä, T
阿尔茨海默病(AD)的发病机制尚不清楚，尽管在过去的20年里，临床诊断标准已经存在，AD的神经病理学也得到了非常详细的研究。本研究探讨了在寻找诊断生物标志物方面的某些问题，以及在AD病程及其鉴别诊断的随访中的某些问题，并报告了我们与其他研究相比较的一些观察结果。这些包括蛋白质、遗传和神经成像标记物。讨论了生物标记物的定义和检索策略。
The etiopathogenesis of Alzheimer's disease (AD) is still unclear, although clinical diagnostic criteria exist and the neuropathology of AD has been studied in great detail during the last 20 years. The present study addresses certain problems in the search for biological markers for the diagnosis, as well as in the follow-up of the course of AD and its differential diagnosis and reports some of our own observations in comparison with other studies. These include protein, genetic and neuroimaging markers. The definitions of biological markers and search strategies are also discussed.