Serotonin transporter promoter polymorphism influences topography of inhibitory motor control
Serotonin transporter promoter polymorphism influences topography of inhibitory motor control
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DOI：
10.1017/s1461145799001455
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发表时间：
1999-06-01
影响因子：
4.8
通讯作者：
Lesch, KP
中科院分区：
文献类型：
--
作者：
Fallgatter, AJ;Jatzke, S;Lesch, KP
前额叶皮层参与运动控制并受到血清素能活动的调节。血清素转运蛋白 (5-HTT) 是血清素能神经传递的主要调节因子，因此可能影响运动控制。5-HTT 连接多态性区域 (5-HTTLPR) 的短等位基因与长变体 (I) 相比，与较少的 5-HTT 表达和功能相关。称为“Go-和NoGo-质心位置”的神经生理学参数代表连续性能测试（CPT）引发的运动反应的执行和抑制的特征脑电基质。在本研究中，在 23 名健康受试者中调查了 5-HTTLPR 基因型对质心位置的影响。与具有两个长等位基因的组（1/I，3.34 +/- 0.49；t = 2.66 p < 0.05）相比，短等位基因组的 NoGo 质心（而非 Go 质心）的位置明显更靠前（s/s 和 s/l 中的平均电极位置，2.86 +/- 0.37）。各组之间的年龄、性别和测试表现没有差异。结果表明，5-HTTLPR 基因型依赖性 5-HTT 功能与抑制性运动控制的神经生理学评估地形相关，并为遗传对中枢血清素能和运动功能的影响提供了进一步的证据。
The prefrontal cortex participates in motor control and is modulated by serotonergic activity. The serotonin transporter (5-HTT) is a major regulator of serotonergic neurotransmission and may thus influence motor control The short allele (s) of the 5-HTT linked polymorphic region (5-HTTLPR) is associated with less 5-HTT expression and function than the long variant (I). The neurophysiological parameters termed 'Go- and NoGo-centroid location' represent characteristic brain electrical substrates of the execution and inhibition of motor response elicited by the Continuous Performance Test (CPT). In the present study, the impact of the 5-HTTLPR genotype on the centroid locations was investigated in 23 healthy subjects. The NoGo-centroid, but not the Go-centroid, was located significantly more anteriorly in the short allele group (mean electrode location in s/s and s/l, 2.86 +/- 0.37) compared to the group with two long alleles (1/I, 3.34 +/- 0.49; t = 2.66 p < 0.05). Age, gender, and test performance did not differ between groups. The results indicate that 5-HTTLPR genotype dependent 5-HTT function is associated with the neurophysiologically assessed topography of inhibitory motor control and provides further evidence for a genetic influence on central serotonergic and motor function.