Perceptions of generic medication in the general population, doctors and pharmacists: a systematic review.
Perceptions of generic medication in the general population, doctors and pharmacists: a systematic review.
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DOI：
10.1136/bmjopen-2015-008915
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发表时间：
2015-12-15
期刊：
影响因子：
2.9
通讯作者：
Petrie KJ
中科院分区：
文献类型：
--
作者：
Colgan S;Faasse K;Martin LR;Stephens MH;Grey A;Petrie KJ
调查对仿制药的负面看法，并评估持有这些看法的非专业人士、医生和药剂师的比例。
一项观察性研究的系统综述。
MEDLINE、EMBASE、PsycInfo和Scopus数据库。
1980年后以英文发表的横断面研究和前瞻性研究的定量数据，使用自我报告的方法来评估对仿制药的看法，以所评估的总样本的百分比呈现。
在筛选了2737篇文章后，52篇文章被纳入最终分析。很大比例的医生、药剂师和非专业人士对仿制药有负面看法。与医生（28.7%，27.5% - 29.9%）和药剂师（23.6%，21.2% - 26.2%）相比，非专业人士明显更有可能认为仿制药不如品牌药有效（35.6%，95%置信区间34.8% - 36.4%），p < 0.0001。与医生（28.0%，26.3% - 29.9%）相比，药剂师（33.4%，31.0% - 35.9%）明显更有可能认为仿制药质量不如品牌药，p = 0.0006，与非专业人士（25.1%，24.2% - 26.0%）相比也是如此，p < 0.0001。与药剂师（17.6%，15.3% - 20.1%）和非专业人士（18.8%，17.8% - 19.8%）相比，医生认为仿制药比品牌药引起更多副作用（24.4%，22.2% - 26.9%），p < 0.0001。与非专业人士（18.0%，17.0% - 19.0%）相比，医生（28.5%，26.9% - 30.2%）和药剂师（25.4%，21.4% - 29.9%）对仿制药的安全性担忧明显更多，p ≤ 0.0002。与医生（24.1%，22.0% - 26.4%）和药剂师（11.0%，9.6% - 12.7%）相比，更大比例的非专业人士对仿制药替代持负面态度（34.0%，33.2% - 34.9%），p < 0.0001。在普通人群或医生群体中，对仿制药的负面看法比率似乎没有随时间发生实质性变化，p ≥ 0.431，但在研究期间，药剂师的这种负面观念呈下降趋势，p = 0.034。
很大比例的医生、药剂师和非专业人士对仿制药持有负面看法。这些态度很可能对仿制药的更广泛使用构成障碍。
To investigate negative perceptions about generic medicines and evaluate the proportions of lay people, doctors and pharmacists who hold these perceptions. A systematic review of observational studies. MEDLINE, EMBASE, PsycInfo and Scopus. Quantitative data from cross-sectional and prospective studies published in English after 1980, using self-report measures to evaluate perceptions about generic medicines, presented as percentages of the total sample assessed. After screening 2737 articles, 52 articles were included in the final analysis. A high proportion of doctors, pharmacists and lay people had negative perceptions of generics. Lay people were significantly more likely to view generics as less effective than branded medication (35.6%, 95% CI 34.8% to 36.4%) compared to doctors (28.7%, 27.5% to 29.9%) and pharmacists (23.6%, 21.2% to 26.2%), p<0.0001. Pharmacists (33.4%, 31.0% to 35.9%) were significantly more likely to believe generics were of inferior quality compared to branded medication than were doctors (28.0%, 26.3% to 29.9%), p=0.0006, and lay people (25.1%, 24.2% to 26.0%), p<0.0001. Doctors believed generics caused more side effects than branded medication (24.4%, 22.2% to 26.9%), compared to pharmacists (17.6%, 15.3% to 20.1%) and lay people (18.8%, 17.8% to 19.8%), p<0.0001. Doctors (28.5%, 26.9% to 30.2%) and pharmacists (25.4%, 21.4% to 29.9%) had significantly more safety concerns about generics than did lay people (18.0%, 17.0% to 19.0%), p≤0.0002. A greater proportion of lay people felt negatively about generic substitution (34.0%, 33.2% to 34.9%), compared to doctors (24.1%, 22.0% to 26.4%) and pharmacists (11.0%, 9.6% to 12.7%), p<0.0001. Rates of negative perceptions of generics do not appear to have changed substantially over time in the general population or among physician groups, p≥0.431, but such negative beliefs show a decreasing trend in pharmacists over the study period, p=0.034. A significant proportion of doctors, pharmacists and lay people hold negative perceptions of generic medicines. It is likely these attitudes present barriers to the wider use of generics.