PEDUNCULOPONTINE-EVOKED EXCITATION OF SUBSTANTIA NIGRA NEURONS IN THE RAT
PEDUNCULOPONTINE-EVOKED EXCITATION OF SUBSTANTIA NIGRA NEURONS IN THE RAT
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DOI：
10.1016/0006-8993(84)90339-1
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
PACITTI, C
中科院分区：
文献类型：
--
作者：
SCARNATI, E;CAMPANA, E;PACITTI, C
研究了电刺激桥脚被盖核对大鼠黑质特定神经元整体活动的影响。实验在完整的大鼠以及患有慢性双侧小脑深部核电解损伤或同侧丘脑下核急性损伤的动物中进行。记录到的主要反应是黑质致密细胞和网状细胞的兴奋（后者中的许多是输出神经元，因为它们是由上丘反向激活的）。可以区分出两种类型的激发。第一个是直接正交激发（潜伏期2.9±-）。1.6女士;3.7 .+-。1.9毫秒)。第二个是稀疏且不太明显的激活（延迟5.2 .+-）。1.8女士;持续时间13.0 .+-。3.0毫秒)。这两种类型的兴奋是完整大鼠唯一记录到的反应（10/51,19.6%，正形激活和10/51,19.6%，弥漫性激活）。记录前7 ~ 21天，小脑核被破坏后，两种神经元仍有兴奋（分别为10/59,16.9%和15/59,25.4%），而少数神经元（3/59,5.0%）被抑制。丘脑下核损伤时，正视反应仍存在（9/42,21.4%），而弥漫性兴奋明显减少（3/42,7.1%），出现较多抑制（6/42,14.2%）。一小部分细胞（12/85,14.1%）从对侧桥脚核通过正交或弥漫兴奋兴奋。同侧桥脚核反向激活的神经元总数为9/152（5.9%）。桥脚被盖核通过可能的直接连接或通过丘脑下核的多突触通路向黑质提供双重兴奋输入。来自黑质两侧的一些细胞依次向外投射到桥脚被盖核。大鼠小脑深部核的输出纤维在黑质中没有突触。
The effects of electrical stimulation of the nucleus tegmenti pedunculopontinus on the unitary activity of identified neurons of the rat substantia nigra were studied. The experiments were carried out in intact rats as well as in animals bearing either chronic bilateral electrolytic lesions of the deep cerebellar nuclei or an acute lesion of the ipsilateral subthalamic nucleus. Excitation of both compacta and reticulata cells of the substantia nigra (many of the latter being output neurons since they are antidromically activated from the superior colliculus) was the predominant response recorded. Two types of excitations could be distinguished. The 1st was a direct orthodromic excitation (latency 2.9 .+-. 1.6 ms; duration 3.7 .+-. 1.9 ms). The 2nd was a sparse and less pronounced activation (latency 5.2 .+-. 1.8 ms; duration 13.0 .+-. 3.0 ms). These 2 types of excitation were the only responses recorded in intact rats (10/51, 19.6%, orthodromic and 10/51, 19.6%, diffuse activation). When the cerebellar nuclei were destroyed 7-21 days prior to the recording, both excitations were still found (10/59, 16.9% and 15/59, 25.4%, respectively), whereas a minority (3/59, 5.0%) of neurons were inhibited. When the subthalamic nucleus was lesioned the orthodromic response was still present (9/42, 21.4%) whereas the occurrence of the diffuse excitation greatly decreased (3/42, 7.1%) and a greater number of inhibitions (6/42, 14.2%) appeared. A small population of cells (12/85, 14.1%) were excited from the contralateral pedunculopontine nucleus either by the orthodromic or by the diffuse excitation. The total number of nigral neurons antidromically activated from the ipsilateral pedunculopontine nucleus was 9/152 (5.9%). The nucleus tegmenti pedunculopontinus gives a dual excitatory input to the substantia nigra either through a probable direct connection or through a polysynaptic pathway via the subthalamic nucleus. A few cells from both parts of the substantia nigra, in turn, project back to the nucleus tegmenti pedunculopontinus. Output fibers from the deep cerebellar nuclei do not synapse in the substantia nigra in the rat.