Trachea-Derived Dpp Controls Adult Midgut Homeostasis in Drosophila
Trachea-Derived Dpp Controls Adult Midgut Homeostasis in Drosophila
复制标题
气管衍生的 dpp 控制果蝇成年中肠稳态。
DOI：
10.1016/j.devcel.2012.12.010
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发表时间：
2013-01-28
影响因子：
11.8
通讯作者：
Lin, Xinhua
中科院分区：
文献类型：
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作者：
Li, Zhouhua;Zhang, Yan;Lin, Xinhua
成体组织中的稳态由常驻干细胞及其后代维持。关于器官-器官相互作用对组织稳态的调节知之甚少。在这里，我们证明了气管源性十Pentaplegic（Dpp）是果蝇中主要的骨形态发生蛋白配体，对于成年中肠稳态至关重要。我们发现，Dpp信号主要在肠上皮细胞（EC）中被激活。EC中Dpp信号的耗尽导致过量的肠干细胞样细胞及其后代。重要的是，我们发现Dpp在气管细胞中特异性表达，气管细胞通过内脏肌肉到达肠细胞。气管细胞中dpp表达的缺失表型模仿EC中Dpp功能缺失缺陷。我们的数据表明，果蝇气管不仅交换空气的身体需要，但也产生了Dpp形态必须为邻近组织的稳态。这项工作将提供重要的见解组织内稳态控制机制的器官间通讯。
Homeostasis in adult tissues is maintained by resident stem cells and their progeny. Little is known about the regulation of tissue homeostasis by organ-organ interaction. Here we demonstrate that trachea-derived Decapentaplegic (Dpp), the main bone morphogenetic protein ligand in Drosophila, is essential for adult midgut homeostasis. We show that Dpp signaling is primarily activated in enterocytes (ECs). Depletion of Dpp signaling in ECs results in excess amounts of intestinal stem-cell-like cells and their progeny. Importantly, we find that Dpp is expressed specifically in tracheal cells that reach the intestinal cells through the visceral muscles. Depletion of dpp expression in tracheal cells phenocopies the Dpp loss-of-function defects in ECs. Our data demonstrate that the Drosophila trachea not only exchanges air for bodily needs but also produces a Dpp morphogen essential for neighboring tissue homeostasis. This work will provide important insights into the mechanisms of tissue homeostasis control by interorgan communication.