Chemoprevention of colon cancer by minor dietary constituents and their synthetic analogues.
Chemoprevention of colon cancer by minor dietary constituents and their synthetic analogues.
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通过次要膳食成分及其合成类似物对结肠癌进行化学预防。
DOI：
10.1006/pmed.1996.0017
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发表时间：
1996
影响因子：
5.1
通讯作者：
Reddy,BS
中科院分区：
文献类型：
--
作者：
Reddy,BS
大肠癌是美国和其他西方国家癌症死亡的主要原因之一。基于流行病学和机制研究，临床前研究旨在评估几种非甾体类抗炎药（NSAID）和植物化学物质及其合成类似物在结肠癌发生中的化学预防效果。这些研究表明，NSAID如吡罗昔康、布洛芬、阿司匹林和舒林酸、d，l-α-二氟甲基鸟氨酸、奥替普拉、茴香脑三嗪和二烯丙基二硫化物可抑制结肠腺癌。这些结果为人类临床试验提供了令人信服的理由。
Large bowel cancer is one of the leading causes of cancer deaths in the United States and other Western countries. Based on epidemiologic and mechanistic studies, preclinical studies were designed to evaluate the chemopreventive efficacy of several nonsteroidal antiinflammatory drugs (NSAIDs) and phytochemicals and their synthetic analogues in colon carcinogenesis. These studies demonstrated that NSAIDs such as piroxicam, ibuprofen, aspirin and sulindac,d,l-α-difluoromethylornithine, oltipraz, anethole trithione, and diallyl disulfide inhibited colon adenocarcinomas. These results provide compelling rationale to pursue clinical trials in humans.