Mitochondrial dynamics: functional link with apoptosis.
Mitochondrial dynamics: functional link with apoptosis.
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DOI：
10.1155/2012/821676
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发表时间：
2012
影响因子：
--
通讯作者：
Mihara K
中科院分区：
文献类型：
--
作者：
Otera H;Mihara K
线粒体参与多种生理过程，如三磷酸腺苷的产生、脂代谢、铁硫簇的生物发生和钙缓冲等。线粒体因细胞条件而频繁融合和分裂，其形态发生动态变化，这些动态变化是细胞凋亡的重要组成部分。调控线粒体动力学的大型GTPase家族蛋白的发现，以及对线粒体融合和分裂在细胞凋亡中作用的新见解，为理解细胞凋亡的分子机制提供了重要线索。本文就线粒体动力学在哺乳动物细胞凋亡和细胞病理生理学中的作用作一简要综述。
Mitochondria participate in a variety of physiologic processes, such as ATP production, lipid metabolism, iron-sulfur cluster biogenesis, and calcium buffering. The morphology of mitochondria changes dynamically due to their frequent fusion and division in response to cellular conditions, and these dynamics are an important constituent of apoptosis. The discovery of large GTPase family proteins that regulate mitochondrial dynamics, together with novel insights into the role of mitochondrial fusion and fission in apoptosis, has provided important clues to understanding the molecular mechanisms of cellular apoptosis. In this paper, we briefly summarize current knowledge of the role of mitochondrial dynamics in apoptosis and cell pathophysiology in mammalian cells.