Subchondral Bone Trabecular Integrity Predicts and Changes Concurrently With Radiographic and Magnetic Resonance Imaging-Determined Knee Osteoarthritis Progression
Subchondral Bone Trabecular Integrity Predicts and Changes Concurrently With Radiographic and Magnetic Resonance Imaging-Determined Knee Osteoarthritis Progression
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DOI：
10.1002/art.37970
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发表时间：
2013-07-01
影响因子：
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通讯作者：
Charles, H. Cecil
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文献类型：
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作者：
Kraus, Virginia Byers;Feng, Sheng;Charles, H. Cecil
目的评估软骨下骨小梁完整性（BTI）的X线片作为膝关节骨关节炎（OA）progression.MethodsLongitudinal（基线，12个月，24个月）膝关节X线片的预测60名女性受试者与膝关节OA。通过12个月和24个月影像学内侧间室最小关节间隙宽度（JSW）和内侧关节间隙面积（JSA）的变化以及磁共振成像上的内侧胫骨和股骨软骨体积来定义OA进展。使用市售软件通过分形特征分析来分析内侧胫骨平台的BTI。BTI的受试者工作特征（ROC）曲线用于预测OA进展参数的5%变化。基于12个月和24个月JSA的变化，垂直骨小梁的基线BTI（线性和二次）预测膝关节OA进展（P < 0.01，24个月），胫骨的24个月变化（P < 0.05），而不是股骨，软骨体积，以及JSW的24个月变化（P = 0.05）。使用基线BTI两项的ROC曲线预测24个月内以下OA进展参数的变化为5%，准确度高，如曲线下面积测量所反映的：JSW 81%，JSA 85%，胫骨软骨体积75%和股骨软骨体积85%。在BTI的变化也显着相关（P < 0.05）与同期的变化，在JSA超过12和24个月，并与胫骨软骨体积的变化超过24 months.ConclusionBTI预测结构性OA进展确定的放射学和MRI结果。因此，BTI可能值得研究，作为OA研究和临床试验的结局指标。
ObjectiveTo evaluate subchondral bone trabecular integrity (BTI) on radiographs as a predictor of knee osteoarthritis (OA) progression.MethodsLongitudinal (baseline, 12-month, and 24-month) knee radiographs were available for 60 female subjects with knee OA. OA progression was defined by 12- and 24-month changes in radiographic medial compartment minimal joint space width (JSW) and medial joint space area (JSA), and by medial tibial and femoral cartilage volume on magnetic resonance imaging. BTI of the medial tibial plateau was analyzed by fractal signature analysis using commercially available software. Receiver operating characteristic (ROC) curves for BTI were used to predict a 5% change in OA progression parameters.ResultsIndividual terms (linear and quadratic) of baseline BTI of vertical trabeculae predicted knee OA progression based on 12- and 24-month changes in JSA (P < 0.01 for 24 months), 24-month change in tibial (P < 0.05), but not femoral, cartilage volume, and 24-month change in JSW (P = 0.05). ROC curves using both terms of baseline BTI predicted a 5% change in the following OA progression parameters over 24 months with high accuracy, as reflected by the area under the curve measures: JSW 81%, JSA 85%, tibial cartilage volume 75%, and femoral cartilage volume 85%. Change in BTI was also significantly associated (P < 0.05) with concurrent change in JSA over 12 and 24 months and with change in tibial cartilage volume over 24 months.ConclusionBTI predicts structural OA progression as determined by radiographic and MRI outcomes. BTI may therefore be worthy of study as an outcome measure for OA studies and clinical trials.