Enhancement of intracellular glutathione protects endothelial cells against oxidant damage.
Enhancement of intracellular glutathione protects endothelial cells against oxidant damage.
复制标题
细胞内谷胱甘肽的增强可保护内皮细胞免受氧化损伤。
DOI：
10.1016/s0006-291x(85)80154-6
复制
发表时间：
1985
影响因子：
3.1
通讯作者：
C. Rosano
中科院分区：
文献类型：
--
作者：
M. Tsan;Ellen H. Danis;P. Vecchio;C. Rosano
We studied the role of glutathione in the endothelial cell defense against H2O2damage. Treatment of endothelial cells with buthionine sulfoximine, an irreversible inhibitor of γ-glutamylcysteine synthetase, depleted the cells of GSH, while L-2-oxothiazolidine-4-carboxylate, an effective intracellular cysteine delivery agent, markedly enhanced endothelial cell GSH concentration. Depletion of intracellular GSH sensitized the endothelial cells to injury by H2O2either preformed or generated by the glucose-glucose oxidase system. In contrast, an increase of intracellular GSH protected the cells from H2O2damage. There was an inverse, linear relationship between the intracellular GSH concentrations and killing of endothelial cells by H2O2. Our results suggest that enhancement of endothelial cell GSH may be an alternative approach toward the prevention of oxidant-induced endothelial damage such as adult respiratory distress syndrome.
谷胱甘肽合成的抑制增强了巯基反应性抗肿瘤药物对小鼠肿瘤细胞的溶解。
DOI：
10.1172/jci110766
发表时间：
1983
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Arrick,BA;Nathan,CF;Cohn,ZA
通讯作者：
Cohn,ZA
DOI：
10.1016/s0021-9258(19)68180-9
发表时间：
1982-02
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
B. Arrick;C. Nathan;O. Griffith;Z. Cohn
通讯作者：
B. Arrick;C. Nathan;O. Griffith;Z. Cohn