Human-microorganism mutualism theory: Possible mechanisms for the delayed chronic wound healing process
Human-microorganism mutualism theory: Possible mechanisms for the delayed chronic wound healing process
复制标题
人体-微生物互利共生理论：慢性伤口愈合过程延迟的可能机制
DOI：
10.1016/j.mehy.2020.109720
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Cheng B
中科院分区：
文献类型：
--
作者：
Mengru Pang;Zexin Yao;Caihong Chen;Xiaoxuan Lei;Cheng B
皮肤微生物植物群被认为可以牵连皮肤健康，并且最近的许多报告指出微生物组的生态失调与疾病之间的密切联系。微生物群的变化，包括多样性、物种和丰度，已经在疾病状态中得到证实，并且认为这些变化可能导致感染和使人衰弱的伤口的慢性化。经有效的治疗后，微生态失调得到逆转，但抗生素治疗对皮肤病无明显临床感染的积极作用。将微生物组与“第二基因组”进行比较，并表明它们与人类共存是共同进化的结果。目前的研究表明，皮肤表面的微生物群落应该有一个理想的最佳状态，可以有效地调节免疫耐受，有助于避免外界致病菌的入侵，那么身体就可以处于一个相对健康的状态。在本文中，我们假设，未能维持微生物与人类之间的和谐关系是我们遭受大多数皮肤疾病的原因，包括慢性不愈合伤口。因此，皮肤微生物群失调理论可以帮助我们更好地理解伤口形成的机制和伤口治疗中遇到的问题。
Skin microbial flora was believed to can implicate skin health, and many recent reports point out a close linkage between the dysbiosis of the microbiome with the disease. Changes of microbiota, including diversity, species, and abundance, have been demonstrated in disease states, and it was believed the changes may cause infection and chronicity of the debilitating wounds. And it was been found a reverse of the dysbiosis after the effective treatment, but it failed to find a positive effect of antibiotic therapy on skin disease without significant clinical infection. The microbiomes were compared to the ‘second gene reservoir’, and indicated that their co-existing with the human being is a result of co-evolution. The current studies have shown that the microbial community on the skin surface should have an ideal optimal state, which can effectively regulate the immune tolerance and help to avoid the invasion of external pathogenic bacteria, then the body can be in a relatively healthy state. In this paper, we hypothesized that failing to maintain the harmonious relationship between microbes and human beings is the reason we suffering from most skin diseases, including chronic non-healing wounds. Thus, the dysbiosis of skin microbiota theory can help us better understand the mechanism of wound formation and problems encountered in wound treatment.