Polarized sorting of AMPA receptors to the somatodendritic domain is regulated by adaptor protein AP-4
Polarized sorting of AMPA receptors to the somatodendritic domain is regulated by adaptor protein AP-4
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DOI：
10.1016/j.neures.2009.05.007
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发表时间：
2009-09-01
影响因子：
2.9
通讯作者：
Yuzaki, Michisuke
中科院分区：
文献类型：
--
作者：
Matsuda, Shinji;Yuzaki, Michisuke
神经元是高度极化的细胞，包括体树突和轴突结构域。为了实现适当的神经元功能，例如神经传递和突触可塑性，膜蛋白必须运输到精确的位置。α-氨基-3-羟基-5-甲基-4-异恶唑丙酸型谷氨酸受体（AMPA受体）是定位于体树突结构域的膜蛋白。AMPA受体介导兴奋性突触传递：因此，AMPA受体的细胞内运输的调节在突触可塑性中具有关键作用。了解调节AMPA受体运输的分子机制对于进一步了解神经元功能至关重要。尽管它的重要性，然而，神经元如何选择性地运输AMPA受体的体树突域在很大程度上是未知的。在这篇更新文章中，我们讨论了最新的研究进展的机制，体树突靶向AMPA受体在神经元。(C)2009年爱思唯尔爱尔兰有限公司和日本神经科学学会。All rights reserved.
Neurons are highly polarized cells comprising somatodendritic and axonal domains. For proper neuronal function, such as neurotransmission and synaptic plasticity, membrane proteins must be transported to precise positions. alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid-type glutamate receptors (AMPA receptors) are membrane proteins localized in the somatodendritic domain. AMPA receptors mediate excitatory synaptic transmission: thus, regulation of the intracellular trafficking of AMPA receptors has a critical role in synaptic plasticity. An understanding of the molecular mechanisms that regulate AMPA receptor trafficking is essential for gaining further insight into neuronal function. Despite its importance, however, how neurons selectively transport AMPA receptors to the somatodendritic domain is largely unknown. In this Update Article, we discuss recent progress in studies of the mechanisms underlying the somatodendritic targeting of AMPA receptors in neurons. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.