How coupling determines the entrainment of circadian clocks
How coupling determines the entrainment of circadian clocks
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DOI：
10.1140/epjb/e2011-20337-1
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发表时间：
2011-08-01
影响因子：
1.6
通讯作者：
Herzel, H.
中科院分区：
文献类型：
--
作者：
Bordyugov, G.;Granada, A. E.;Herzel, H.
自主生物钟驱动生理和行为的日常节奏。视交叉上核(SCN)是一个相互耦合的神经元网络，是一种强大的自我维持的昼夜节律起搏器。这种计时器与环境明暗周期的同步对生物体的健康至关重要。最近的一项理论和实验研究表明，耦合控制着生物钟的夹带范围。我们应用耦合振子理论分析了扩散耦合和平均场耦合如何影响相互作用细胞的夹带范围。平均场耦合导致弱振子的振幅扩展，从而减小了夹带范围。我们还证明了耦合决定了同步SCN网络的刚性，即扰动时的松弛速率。我们的模拟和使用一般振子模型的分析计算有助于阐明耦合如何决定SCN的夹带。我们的理论框架有助于解释实验数据。
Autonomous circadian clocks drive daily rhythms in physiology and behaviour. A network of coupled neurons, the suprachiasmatic nucleus (SCN), serves as a robust self-sustained circadian pacemaker. Synchronization of this timer to the environmental light-dark cycle is crucial for an organism's fitness. In a recent theoretical and experimental study it was shown that coupling governs the entrainment range of circadian clocks. We apply the theory of coupled oscillators to analyse how diffusive and mean-field coupling affects the entrainment range of interacting cells. Mean-field coupling leads to amplitude expansion of weak oscillators and, as a result, reduces the entrainment range. We also show that coupling determines the rigidity of the synchronized SCN network, i.e. the relaxation rates upon perturbation. Our simulations and analytical calculations using generic oscillator models help to elucidate how coupling determines the entrainment of the SCN. Our theoretical framework helps to interpret experimental data.