Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States
Human Risk of Infection with Borrelia burgdorferi, the Lyme Disease Agent, in Eastern United States
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DOI：
10.4269/ajtmh.2012.11-0395
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发表时间：
2012-02-01
影响因子：
3.3
通讯作者：
Fish, Durland
中科院分区：
文献类型：
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作者：
Diuk-Wasser, Maria A.;Hoen, Anne Gatewood;Fish, Durland
绘制了美国东部人类感染伯氏疏螺旋体（导致莱姆病的蜱传病原体）风险的地理模式。该地图是基于标准化的现场采样，在304个地点的肩突硬蜱宿主寻求性蜱感染B的密度。与人类感染风险密切相关。受感染蝗虫的存在和密度的风险因素被用来模拟一个连续的8公里x8公里分辨率的人类风险预测表面，包括每个像素的置信区间。在东北部和上中西部发现了不连续的莱姆病风险疫源地，过渡区包括未感染I型莱姆病的地点。scapularis种群。鉴于莱姆病的频繁诊断不足和过度诊断，该地图可以作为指导监测，控制和预防工作的工具，并作为跟踪感染传播研究的基线。
The geographic pattern of human risk for infection with Borrelia burgdorferi sensu stricto, the tick-borne pathogen that causes Lyme disease, was mapped for the eastern United States. The map is based on standardized field sampling in 304 sites of the density of Ixodes scapularis host-seeking nymphs infected with B. burgdorferi, which is closely associated with human infection risk. Risk factors for the presence and density of infected nymphs were used to model a continuous 8 km x 8 km resolution predictive surface of human risk, including confidence intervals for each pixel. Discontinuous Lyme disease risk foci were identified in the Northeast and upper Midwest, with a transitional zone including sites with uninfected I. scapularis populations. Given frequent under- and over-diagnoses of Lyme disease, this map could act as a tool to guide surveillance, control, and prevention efforts and act as a baseline for studies tracking the spread of infection.