Treating Prostate Cancer in Elderly Men: How Does Aging Affect the Outcome?
Treating Prostate Cancer in Elderly Men: How Does Aging Affect the Outcome?
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DOI：
10.1007/s11864-011-0160-6
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发表时间：
2011-09-01
影响因子：
4.3
通讯作者：
Mohile, Supriya G.
中科院分区：
文献类型：
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作者：
Shelke, Abhay R.;Mohile, Supriya G.
前列腺癌（PCa）是美国第二常见的癌症，并且仍然是西方世界第二大死亡原因。由于前列腺癌男性患者的诊断中位年龄大于75岁，前列腺癌可被视为一种老年疾病。在决策过程中需要考虑几个疾病特异性因素（例如，分期、肿瘤分级、前列腺特异性抗原（PSA）水平）以及患者特异性因素（例如，年龄、合并症和功能状态）。为了纳入这些重要因素以便为老年个体选择最佳治疗方案，已经发表了几个决策模型，然而它们在临床实践中的效用仍鲜为人知。当前前列腺癌患者的管理指南没有针对老年人提出具体建议。显然，有必要提高我们对老年、合并症及其对预期结果影响之间复杂相互关系的理解。
Prostate Cancer (PCa) is the second most common cancer in United States and remains the second leading cause of death in the Western world. Because the median age of diagnosis for men with prostate cancer is greater than 75 years, PCa can be considered a disease of the elderly. Several disease-specific factors (e.g., stage, tumor grade, prostate-specific antigen (PSA) level) and patient-specific factors (e.g., age, co-morbidity, and functional status) need to be considered in the decision-making process. In an attempt to incorporate these important factors to select optimal treatment for older individuals, several decision models have been published, yet their utility in clinical practice remains poorly understood. Current guidelines for the management of patients with PCa do not make specific recommendations for the elderly. Clearly there is a need to improve our understanding of the complex interrelationships between old age, co-morbidities, and their impact on expected outcomes.