Metabolic syndrome and C-reactive protein in the general population - JMS Cohort Study
Metabolic syndrome and C-reactive protein in the general population - JMS Cohort Study
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DOI：
10.1253/circj.71.26
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发表时间：
2007-01-01
影响因子：
3.3
通讯作者：
Kajii, Eiji
中科院分区：
文献类型：
--
作者：
Ishikawa, Shizukiyo;Kayaba, Kazunori;Kajii, Eiji
背景 近年来，一些研究表明，代谢综合征 (MS) 与炎症相关，以高敏 C 反应蛋白 (hsCRP) 为标志，但基于人群的研究很少，特别是在日本。 方法和结果 研究对象是 1992 年至 1995 年间检查的 2,191 名男性和女性，并作为自治医科大学队列研究的一部分，使用必要的数据来确定 MS。 CRP通过比浊法测量。有 109 名受试者被定义为患有 MS（5.0%），男性 MS 病例比例（9.4%）高于女性（1.8%）。 NIS 组的 CRP 几何平均值和中位值高于非 MS 组（几何平均值；p < 0.001，中位值：MS 组为 0.312 mg/L，MS 组为 0.122 mg/L）。在将受试者除以 CRP 三分位数后，MS 比例随 CRP 增加而增加（比值比，95% 置信区间 1(st) 三分位数作为参考；2(nd) 三分位数：2.9, 1.5-5.9，3(rd) 三分位数：5.7, 3. 1-11.1）。 结论 在以下情况下，通过 hsCRP 浓度测量的炎症升高：日本普通人群中多发性硬化症。将来应该检查纵向数据。
Background In recent years some studies have shown that metabolic syndrome (MS) is associated with inflammation, indicated by high-sensitivity C-reactive protein (hsCRP), but there have been few population-based studies, especially in Japan.Methods and Results The study subjects were 2,191 men and women examined between 1992 and 1995 with the necessary data to ascertain MS as part of the Jichi Medical School Cohort Study. CRP was measured by nephelometry. There were 109 subjects defined as having MS (5.0%), and the proportion of MS cases was higher in men (9.4%) than in women (1.8%). Geometric mean and median CRP in the NIS group was higher than that in the non-MS (geometric mean; p < 0.001, median: 0.312 mg/L in MS and 0.122 mg/L). Proportion of MS increased with CRP, after the subjects were divided by tertile of CRP (odds ratio, 95% confidence interval 1(st) tertile as a reference; 2(nd) tertile: 2.9, 1.5-5.9, 3(rd) tertile: 5.7, 3. 1-11.1).Conclusion Inflammation, measured by the concentration of hsCRP, was elevated in cases of MS in the general Japanese population. Longitudinal data should be examined in the future.