Telomere length and psychological well-being in patients with chronic heart failure
Telomere length and psychological well-being in patients with chronic heart failure
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DOI：
10.1093/ageing/afp256
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发表时间：
2010-03-01
期刊：
影响因子：
6.7
通讯作者：
van Veldhuisen, Dirk J.
中科院分区：
文献类型：
--
作者：
Huzen, Jardi;van der Harst, Pim;van Veldhuisen, Dirk J.
设计：采用横断面分析。背景：患者因 CHF 体征和症状入院。目的：本研究旨在评估 CHF 患者端粒长度与心理健康之间的关系。方法：通过定量聚合酶链反应测定 890 名纽约心脏协会功能性 II 级至 IV 级 CHF 患者的端粒长度。我们通过经过验证的 RAND-36 问卷评估了感知的心理健康状况。抑郁症状通过流行病学研究中心抑郁量表 (CES-D) 进行评估，D 型人格的存在通过 DS14 进行评估。结果：RAND-36 评分中较低的感知心理健康状况与较短的端粒长度相关。年龄和性别的调整并没有改变我们的研究结果（标准化 beta，0.11；P 值，0.002）。端粒长度与 CES-D 或 DS14 评分无关。结论：CHF 患者感知心理健康状况下降与白细胞端粒长度较短相关。未来的工作应该确定心理压力是否会加速生物衰老。
Design: a cross-sectional analysis was used.Setting: patients were admitted to the hospital with signs and symptoms of CHF.Objective: the study aimed to assess the association between telomere length and psychological well-being in patients with CHF.Methods: telomere length was determined by quantitative polymerase chain reaction in 890 patients with New York Heart Association functional class II to IV CHF. We evaluated the perceived mental health by the validated RAND-36 questionnaire. Depressive symptoms were assessed by the Centre for Epidemiologic Studies Depression scale (CES-D), and the presence of type D personality was evaluated by the DS14.Results: a lower perceived mental health on the RAND-36 score was associated with shorter telomere length. Adjustment for age and gender did not change our findings (standardised beta, 0.11; P-value, 0.002). Telomere length was not associated with the CES-D or DS14 score.Conclusion: decreased perceived mental health is associated with shorter leukocyte telomere length in patients with CHF. Future work should determine whether psychological stress accelerates biological ageing.