Coupling of neurogenesis and angiogenesis after ischemic stroke.
Coupling of neurogenesis and angiogenesis after ischemic stroke.
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缺血性中风后神经发生和血管生成的耦合
DOI：
10.1016/j.brainres.2015.02.042
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发表时间：
2015-10-14
期刊：
影响因子：
2.9
通讯作者：
Jin K
中科院分区：
文献类型：
--
作者：
Ruan L;Wang B;ZhuGe Q;Jin K
中风是世界范围内死亡和严重长期残疾的主要原因。因此，为缺血性卒中患者开发有效的治疗或新的治疗策略至关重要。缺血性卒中通过几种生长因子（包括FGF-2、IGF-1、BDNF、VEGF）和趋化因子（包括SDF-1、MCP-1）促进神经发生。中风诱导的血管生成类似地由许多因子调节，最显著的是eNOS和CSE、VEGF/VEGFR 2和Ang-1/Tie 2。过去十年的重要发现表明，神经发生并不是中风完全功能恢复的唯一考虑因素。血管生成也被证明是关键，在改善中风后神经功能恢复。更重要的是，最近的证据表明，中风诱导的神经发生和血管生成之间很可能存在相互作用或依赖关系。展望未来，阐明中风诱导的神经发生和血管生成之间的这种耦合的潜在机制将是非常重要的，这将为神经修复治疗提供基础。
Stroke is a leading cause of mortality and severe long-term disability worldwide. Development of effective treatment or new therapeutic strategies for ischemic stroke patients is therefore crucial. Ischemic stroke promotes neurogenesis by several growth factors including FGF-2, IGF-1, BDNF, VEGF and chemokines including SDF-1, MCP-1. Stroke-induced angiogenesis is similarly regulated by many factors most notably, eNOS and CSE, VEGF/VEGFR2, and Ang-1/Tie2. Important findings in the last decade have revealed that neurogenesis is not the stand-alone consideration in the fight for full functional recovery from stroke. Angiogenesis has been also shown to be critical in improving post-stroke neurological functional recovery. More than that, recent evidence has shown a highly possible interplay or dependence between stroke-induced neurogenesis and angiogenesis. Moving forward, elucidating the underlying mechanisms of this coupling between stroke-induced neurogenesis and angiogenesis will be of great importance, which will provide the basis for neurorestorative therapy.