Hepatoprotective and TNF-α inhibitory activity of Zosima absinthifolia extracts and coumarins
Hepatoprotective and TNF-α inhibitory activity of Zosima absinthifolia extracts and coumarins
复制标题
DOI：
10.1016/j.fitote.2010.12.007
复制
发表时间：
2011-04-01
期刊：
影响因子：
3.4
通讯作者：
Smejkal, Karel
中科院分区：
文献类型：
--
作者：
Bahadir, Ozlem;Citoglu, Gulcin Saltan;Smejkal, Karel
通过四氯化碳诱导的大鼠肝毒性试验和抑制LPS刺激的THP-1巨噬细胞产生TNF-α，分别评价了Zosima absinthifolia（ZA）提取物和香豆素（+）-columbianadin和（-）-deltoin的潜在保肝和抗炎作用。通过监测ALT/AST水平和组织病理学检查，ZA提取物和香豆素均显示出肝保护活性。通过抑制TNF-α产生证明的抗炎活性被发现对于正己烷根提取物比对于香豆素更高，表明提取物的协同潜力。通过HPLC分析测定提取物中的（-）-deltoin和（+）-columbianadin的浓度。(c)2011 Elsevier B. V.保留所有权利。
Zosima absinthifolia (ZA) extracts and the coumarins (+)-columbianadin and (-)-deltoin were evaluated for their potential hepatoprotective and antiinflamatory effects in a CCl4-induced hepatotoxicity assay in rats and by the inhibition of TNF-alpha production on LPS-stimulated THP-1 macrophages, respectively. Both the ZA extracts and the coumarins showed hepatoprotective activity confirmed by monitoring the ALT/AST levels and by histopathological examination. The antiinflamatory activity, proved by the inhibition of TNF-alpha production, was found to be higher for the n-hexane root extract than for coumarins, suggesting synergic potential of the extract. The concentration of (-)-deltoin and (+)-columbianadin in extracts was determined by HPLC analysis. (c) 2011 Elsevier B.V. All rights reserved.