Robustness effect of gap junctions between Golgi cells on cerebellar cortex oscillations.
Robustness effect of gap junctions between Golgi cells on cerebellar cortex oscillations.
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DOI：
10.1186/2042-1001-1-7
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发表时间：
2011-03-01
期刊：
影响因子：
--
通讯作者：
De Schutter E
中科院分区：
文献类型：
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作者：
Simões de Souza FM;De Schutter E
先前的小脑颗粒层的一维网络建模已经成功地与在体内观察到的小脑皮层振荡的范围相关联。然而，最近发现的间隙连接之间的高尔基体细胞（GoCs），这可能会导致振荡本身，提出了一个问题，间隙连接耦合如何影响GoC和颗粒层振荡。为了研究这个问题，我们开发了一种新的二维计算模型的GoC颗粒细胞（GC）电路之间的间隙连接和没有。由间隙连接耦合的孤立GoCs有很强的倾向产生自发振荡，而不影响其平均放电频率响应于分布式苔藓纤维输入。相反，当GoC在颗粒层中突触连接时，间隙连接增加了振荡的功率，但振荡主要由GoC和GC之间的突触反馈回路驱动，并且差距连接不改变GoC或GC的振荡频率或平均放电率。我们的建模结果表明，GoCs之间的间隙连接增加了小脑皮层振荡的鲁棒性，这些振荡主要由GoCs和GC之间的反馈回路驱动。在我们的模型中观察到的间隙连接对突触驱动振荡的鲁棒性影响可能是一种普遍的机制，也存在于大脑的其他区域。
Previous one-dimensional network modeling of the cerebellar granular layer has been successfully linked with a range of cerebellar cortex oscillations observed in vivo. However, the recent discovery of gap junctions between Golgi cells (GoCs), which may cause oscillations by themselves, has raised the question of how gap-junction coupling affects GoC and granular-layer oscillations. To investigate this question, we developed a novel two-dimensional computational model of the GoC-granule cell (GC) circuit with and without gap junctions between GoCs. Isolated GoCs coupled by gap junctions had a strong tendency to generate spontaneous oscillations without affecting their mean firing frequencies in response to distributed mossy fiber input. Conversely, when GoCs were synaptically connected in the granular layer, gap junctions increased the power of the oscillations, but the oscillations were primarily driven by the synaptic feedback loop between GoCs and GCs, and the gap junctions did not change oscillation frequency or the mean firing rate of either GoCs or GCs. Our modeling results suggest that gap junctions between GoCs increase the robustness of cerebellar cortex oscillations that are primarily driven by the feedback loop between GoCs and GCs. The robustness effect of gap junctions on synaptically driven oscillations observed in our model may be a general mechanism, also present in other regions of the brain.