MECHANISM OF EVAGINATION OF IMAGINAL DISKS OF DROSOPHILA-MELANOGASTER .1. GENERAL CONSIDERATIONS
MECHANISM OF EVAGINATION OF IMAGINAL DISKS OF DROSOPHILA-MELANOGASTER .1. GENERAL CONSIDERATIONS
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DOI：
10.1016/0012-1606(75)90127-x
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发表时间：
1975-01-01
影响因子：
2.7
通讯作者：
FRISTROM, JW
中科院分区：
文献类型：
--
作者：
FRISTROM, D;FRISTROM, JW
外翻盘的形态学和超微结构观察沿着外翻抑制剂，特别是细胞松弛素B（CB）的生化和细胞效应的研究。外翻盘的超微结构描述与特别提到的元素，可能是重要的外翻，特别是微丝和微管。有间接证据表明，CB敏感的微丝分布沿着基底细胞表面可能在外翻中发挥作用。CB对β-蜕皮激素刺激的合成活性没有影响，提出了一个同时需要细胞扁平化和细胞重排的附属物从成虫盘外翻的模型。马赛克和细胞谱系研究的模型的一些影响进行了讨论。
Morphological and ultrastructural observations of evaginating discs are presented along with studies of the biochemical and cellular effects of inhibitors of evagination, particularly cytochalasin B (CB). The ultrastructure of the evaginating disc is described with special reference to elements which might be important in evagination, specifically microfilaments and microtubules. There is circumstantial evidence that CB sensitive microfilaments distributed along the basal cell surface may play a role in evagination. No effects of CB were found on β-ecdysone-stimulated synthetic activities.A model for the evagination of appendages from imaginal discs which requires both cell flattening and cell rearrangement is presented. Some implications of the model for mosaic and cell lineage studies are discussed.