Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: an exploratory randomized controlled trial
Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: an exploratory randomized controlled trial
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DOI：
10.1016/j.nutres.2019.05.003
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发表时间：
2019-07-01
影响因子：
4.5
通讯作者：
Hashimoto, Koichi
中科院分区：
文献类型：
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作者：
Araki, Risa;Fujie, Keiko;Hashimoto, Koichi
橄榄叶富含橄榄苦苷，已被证明对血脂异常、2 型糖尿病和肥胖症具有有益作用。然而，我们之前发现橄榄叶茶 (OLT) 对非肥胖和非糖尿病个体没有显着的健康益处。因此，我们进行这项研究是为了进一步探讨 OLT 对糖尿病前期个体的健康益处，并比较低浓度 OLT (LOLT) 和 OLT 之间的健康益处。我们假设 OLT 对糖尿病前期个体的腹部肥胖以及葡萄糖和脂质代谢有更明显的影响。招募年龄在 40 至 70 岁之间、体重指数为 23.0-29.9 kg/m(2) 且处于糖尿病前期状态的个体，并随机分配到 OLT 组或 LOLT 组。干预措施是每天在进餐时饮用 3 次 330 毫升的测试饮料，持续 12 周。干预后，OLT 组 (n = 28) 的血清对数转化甘油三酯 (P < .05) 和低密度脂蛋白胆固醇 (P < .01) 水平显着下降，且 OLT 组的降低幅度高于 LOLT 组 (n = 29，对数转化甘油三酯：P = .079，低密度脂蛋白胆固醇：P < .05)。尽管两组的体重、腰围和胰岛素水平均无显着变化，但与 LOLT 组相比，OLT 组的空腹血糖水平显着降低 (P < .05)。总之，虽然OLT对腹部肥胖和糖代谢的影响尚不清楚，但已发现OLT具有降脂作用。 (C) 2019 Elsevier Inc. 保留所有权利。
Olive leaves are rich in oleuropein, which has been shown to have beneficial effects on dyslipidemia, type 2 diabetes, and obesity. However, we previously found no significant health benefits of olive leaf tea (OLT) on nonobese and nondiabetic individuals. Thus, we performed this study to further explore the health benefits of OLT in individuals with prediabetes and compare the health benefits between low-concentration OLT (LOLT) and OLT. We hypothesized that OLT will have a more pronounced effect on abdominal obesity as well as glucose and lipid metabolism in prediabetic individuals. Individuals between 40 and 70 years of age with a body mass index of 23.0-29.9 kg/m(2) and prediabetes status were recruited and randomly assigned to the OLT or the LOLT group. The intervention, which was the consumption of 330 mL of the test beverage 3 times daily during mealtime, lasted for 12 weeks. After the intervention, serum levels of log-transformed triglycerides (P < .05) and low-density lipoprotein cholesterol (P < .01) decreased significantly in the OLT group (n = 28), with the reductions higher in the OLT group than those in the LOLT group (n = 29, log-transformed triglycerides: P = .079, low-density lipoprotein cholesterol: P < .05). Whereas body weight, waist circumference, and insulin levels were not significantly changed in both groups, fasting plasma glucose levels in the OLT group were significantly decreased compared to those in the LOLT group (P < .05). In conclusion, although the effect of OLT on abdominal obesity and glucose metabolism remains unclear, OLT has been found to have lipid-lowering effects. (C) 2019 Elsevier Inc. All rights reserved.