The Effect of Catecholaminergic Depletion Within the Prelimbic and Infralimbic Medial Prefrontal Cortex on Recognition Memory for Recency, Location, and Objects
The Effect of Catecholaminergic Depletion Within the Prelimbic and Infralimbic Medial Prefrontal Cortex on Recognition Memory for Recency, Location, and Objects
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DOI：
10.1037/a0023337
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发表时间：
2011-06-01
影响因子：
1.9
通讯作者：
Cassaday, Helen J.
中科院分区：
文献类型：
--
作者：
Nelson, Andrew J. D.;Cooper, Molly T.;Cassaday, Helen J.
有充分的证据表明，内侧前额叶皮层（mPFC）参与识别记忆的不同方面。然而，mPFC是一个异质结构，和前边缘（PL）和边缘下（IL）皮质的再认记忆的贡献还没有被调查。同样，在这些过程中，mPFC内不同的神经调质的作用也知之甚少。为此，我们测试了动物与6-羟多巴胺（6-OHDA）病变的PL和IL mPFC的三个测试的对象识别记忆，需要判断的近因，对象的位置，和对象的身份。在近因任务中，PL和IL的病变严重损害了动物区分旧的（较早出现的）和最近出现的熟悉物体的能力。相对于假手术和PL动物，IL病变也破坏了对象定位任务的性能。然而，这两种病变都保持了对新物体的识别。这些数据证实了以前的报告，即mPFC是不需要的歧视的基础上相对熟悉的个别对象。然而，这些结果表明，PL皮层内的儿茶酚胺是至关重要的相对近的判断，并建议在IL内的神经处理中的整合有关对象的位置的信息可能发挥的作用。
There is good evidence that the medial prefrontal cortex (mPFC) is involved in different aspects of recognition memory. However, the mPFC is a heterogeneous structure, and the contribution of the prelimbic (PL) and infralimbic (IL) cortices to recognition memory has not been investigated. Similarly, the role of different neuromodulators within the mPFC in these processes is poorly understood. To this end, we tested animals with 6-hydroxydopamine (6-OHDA) lesions of the PL and IL mPFC on three tests of object recognition memory that required judgments about recency, object location, and object identity. In the recency task, lesions to both PL and IL severely impaired animals' ability to differentiate between old (earlier presented) and recently presented familiar objects. Relative to sham and PL animals, the IL lesion also disrupted performance on the object location task. However, both lesions left novel object recognition intact. These data confirm previous reports that the mPFC is not required for discriminations based on the relative familiarity of individual objects. However, these results demonstrate that catecholamines within the PL cortex are crucial for relative recency judgments and suggest a possible role for neural processing within the IL in the integration of information about object location.