Prospective study of alcohol consumption and the risk of age-related macular degeneration
Prospective study of alcohol consumption and the risk of age-related macular degeneration
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DOI：
10.1001/archopht.118.5.681
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发表时间：
2000-05-01
影响因子：
--
通讯作者：
Seddon, JM
中科院分区：
文献类型：
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作者：
Cho, EY;Hankinson, SE;Seddon, JM
目的：探讨饮酒与老年性黄斑变性(AMD)发病的关系。方法：对1980~1994年间的女性护士和1986~1994年间的男性医务人员进行前瞻性研究。我们纳入了32764名女性和29488名男性，他们年龄在50岁或以上，在基线上没有被诊断为AMD或癌症，并在他们达到50岁时增加了额外的受试者。他们的酒精摄入量在基线时被评估，并在后续评估中使用经过验证的半定量食物频率问卷进行更新。在对女性和男性分别进行分析后，对酒精与AMD风险的关系进行了汇总估计。结果：截至1994年，在随访结束的1994年，298名女性(697 498人年的随访)和153名男性(229 180人年)诊断出与年龄相关性黄斑变性相关的视力下降20/30或更严重，包括早期、干型和湿型。在控制了年龄、吸烟和其他危险因素后，与不饮酒者相比，饮酒者AMD的合并相对危险度(RR)和95%可信区间(CI)分别为1.0(0.7-2.2)、0.9(0.6-1.4)、1.1(0.7-1.7)、1.3(0.9-1.8)和1.3(0.9-1.8)。在女性中，有一项建议表明，每天饮酒30克或更多的饮酒者患上这种疾病的风险略有增加(相对危险度，1.5；95%可信区间，1.0-2.4)；这仅限于早期和干性饮酒的风险增加(相对危险度，2.0；95%可信区间，1.2-3.4)。结论：这项前瞻性研究不支持适度饮酒与AMD风险之间的负相关关系。
Objective: To describe the relationship between alcohol consumption and the incidence of age-related macular degeneration (AMD).Methods: We conducted a prospective study among female nurses between 1980 and 1994 and among male health professionals between 1986 and 1994. We included 32 764 women and 29 488 men who were 50 years or older, without a diagnosis of AMD or cancer at baseline, and added additional subjects to the analysis as they reached 50 years of age. Their alcohol intake was assessed at baseline and updated during follow-up evaluations using a validated semiquantitative food-frequency questionnaire. After separate analyses for women and men, pooled estimates of the relationship of alcohol to the risk of AMD were calculated.Results: Age-related macular degeneration associated with a visual acuity loss of 20/30 or worse, including the early and dry and wet types was diagnosed in 298 women (from 697 498 person-years of follow-up) and 153 men (229 180 person-years) by 1994, the end of follow-up. After controlling for age, smoking, and other risk factors, the pooled relative risks (RRs) and 95% confidence intervals (CIs) for AMD compared with nondrinkers were 1.0 (0.7-2.2) for drinkers who consumed 0.1 to 4.9 dd of alcohol; 0.9 (0.6-1.4) for 5 to 14.9 gid; 1.1 (0.7-1.7) for 15 to 29.9 g/d; and 1.3 (0.9-1.8) for 30 g/d or more. Among women, there was a suggestion of a modest increased risk of the disease in drinkers who consumed 30 g/d or more (RR, 1.5; 95% CI, 1.0-2.4); this was limited to an increased risk of the early and dry form (RR, 2.0; 95% CI, 1.2-3.4). No specific type of alcohol provided protection against AMD.Conclusion: This prospective study does not support an inverse relationship between moderate alcohol consumption and risk of AMD.