Serum levels of IGFBP7 are elevated during acute exacerbation in COPD patients.
Serum levels of IGFBP7 are elevated during acute exacerbation in COPD patients.
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DOI：
10.2147/copd.s132652
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发表时间：
2017
影响因子：
2.8
通讯作者：
Ying K
中科院分区：
文献类型：
--
作者：
Ruan W;Wu M;Shi L;Li F;Dong L;Qiu Y;Wu X;Ying K
本研究的目的是探讨慢性阻塞性肺疾病（COPD）患者急性加重（AE）期间血清中胰岛素样生长因子结合蛋白7（IGFBP7）的水平。研究人群包括47名AECOPD患者，其中2011年1月至2011年2月期间入组的25名患者（第一组）、2011年12月至2012年8月期间入组的22名患者（第二组）和29名健康对照者。采用化学发光联免疫法检测血清IGFBP7水平。对于第二组患者，在入院当天和出院当天测量IGFBP7和C反应蛋白（CRP）水平。在第一组AECOPD患者中，重症监护病房（ICU；52.92±16.32 ng/mL）的AECOPD患者和非ICU住院的AECOPD患者（40.66±13.9）血清IGFBP7水平显着高于健康受试者（30.3±7.09 ng/mL；P<0.01）。对于第二组AECOPD患者，患者康复后升高的IGFBP7水平降低（34.42±11.88 vs 27.24±7.2 ng/mL；P<0.01）。 AE期间，IGFBP7与CRP之间的相关系数为0.357。在受试者操作特征分析中，区分入院当天和出院当天的 AECOPD 患者，CRP 的曲线下面积为 0.799，IGFBP7 的曲线下面积为 0.663。 AECOPD 期间血清 IGFBP7 水平升高。与 CRP 的表达模式类似，IGFBP7 水平在恢复后降低，表明 IGFBP7 可能具有作为 AECOPD 生物标志物的候选作用。 IGFBP7 和 CRP 之间没有检测到显着的线性相关性，表明这两种分子在评估 AECOPD 中可能发挥不同的作用。需要进一步研究探讨IGFBP7在区分AECOPD表型中的价值。
The purpose of this study was to explore the insulin-like growth factor binding protein 7 (IGFBP7) level in the serum of chronic obstructive pulmonary disease (COPD) patients during acute exacerbation (AE). The study population consisted of 47 AECOPD patients, including 25 patients enrolled between January 2011 and February 2011 (the first group) and 22 patients enrolled from December 2011 to August 2012 (the second group) and 29 healthy controls. Chemiluminescence–linked immunoassay was used to detect serum IGFBP7 levels. For the second group patients, IGFBP7 and C-reactive protein (CRP) levels were measured both on the admission day and on the discharge day. Among the first group AECOPD patients, serum IGFBP7 levels were significantly elevated in AECOPD patients in the intensive care unit (ICU; 52.92±16.32 ng/mL), and in hospitalized AECOPD patients not in ICU (40.66±13.9), compared to healthy subjects (30.3±7.09 ng/mL; P<0.01). For the second group AECOPD patients, the increased IGFBP7 levels reduced after the patients had recovered (34.42±11.88 vs 27.24±7.2 ng/mL; P<0.01). During AE, the correlation coefficient between IGFBP7 and CRP was 0.357. In receiver operating characteristic analysis, the area under the curve was 0.799 for CRP, and 0.663 for IGFBP7 in distinguishing patients with AECOPD on the admission day from the discharge day. Serum IGFBP7 levels were raised during AECOPD. Similar to the expression pattern of CRP, the IGFBP7 levels reduced after convalescence, suggesting that IGFBP7 might have a candidate role as a biomarker of AECOPD. No significant linear correlation was detected between IGFBP7 and CRP, indicating the probable different role for the two molecules in assessing AECOPD. Further study is needed to explore the value of IGFBP7 in differentiating phenotypes of AECOPD.