Downregulation of RAI14 inhibits the proliferation and invasion of breast cancer cells
Downregulation of RAI14 inhibits the proliferation and invasion of breast cancer cells
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DOI：
10.7150/jca.34910
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发表时间：
2019-01-01
影响因子：
3.9
通讯作者：
Zheng, Xinyu
中科院分区：
文献类型：
--
作者：
Gu, Ming;Zheng, Wenhui;Zheng, Xinyu
视黄酸诱导的14（RAI 14）参与不同类型肿瘤的发生发展，但其在乳腺癌中的表达及生物学功能尚不清楚。在目前的研究中，我们证明RAI 14在乳腺癌中高度表达。RAI 14的高表达与乳腺癌的恶性进展呈正相关，提示预后不良。进一步研究发现，RAI 14基因敲低后，通过Akt/Cyclin D1、MMP 2、MMP 9和ZEB 1/E-cadhrin/Vimentin通路调控细胞周期和EMT，从而抑制乳腺癌细胞的增殖、迁移和侵袭。这些发现揭示了RAI 14在乳腺癌进展中的新功能，并表明RAI 14可能成为乳腺癌诊断和治疗的有希望的靶点。
Retinoic acid-induced 14 (RAI14) is involved in the development of different tumor types, however, its expression and biological function in breast cancer are yet unknown. In the current study, we demonstrated that RAI14 was highly expressed in breast cancer. The high expression of RAI14 is positively correlated with the malignant progression of breast cancer and suggests a worse prognosis. Further, we found that knockdown RAI14 inhibits the proliferation, migration and invasion of breast cancer cells by regulating cell cycle and EMT through Akt/Cyclin D1, MMP2, MMP9 and ZEB1/E-cadhrin/Vimentin pathway. These findings revealed a novel function for RAI14 in breast cancer progression and suggest that RAI14 may become a promising diagnostic and therapeutic target for breast cancer.