White matter integrity affected by depressive symptoms in migraine without aura: a tract‐based spatial statistics study
White matter integrity affected by depressive symptoms in migraine without aura: a tract‐based spatial statistics study
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DOI：
10.1002/nbm.2924
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发表时间：
2013-09
影响因子：
2.9
通讯作者：
Dahua Yu;K. Yuan;Ling Zhao;Minghao Dong;Peng Liu;Xuejuan Yang;Jixin Liu;Jinbo Sun;Guangyu Zhou-Guang
中科院分区：
文献类型：
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作者：
Dahua Yu;K. Yuan;Ling Zhao;Minghao Dong;Peng Liu;Xuejuan Yang;Jixin Liu;Jinbo Sun;Guangyu Zhou-Guang
以前的研究已经证明，偏头痛和抑郁症是双向联系的。然而，很少有研究调查白色物质（WM）的完整性受抑郁症状的患者患有无先兆偏头痛（MWoA）。根据本研究中的抑郁自评量表（SDS）评分，将40例MWoA患者分为两组，其中SDS（+）（SDS > 49）组20例，SDS（-）（SDS ≤ 49）组20例。另外，还招募了40名健康参与者作为对照组。采用多个弥散张量成像衍生指数[各向异性分数（FA）、平均扩散率（MD）、径向扩散率（RD）、轴向扩散率（AD）]进行基于道的空间统计分析，以研究所有MWoA患者与所有健康对照之间、每个亚组（SDS（−）组和SDS（+）组）与健康对照之间的WM完整性，SDS（-）和SDS（+）之间的关系。与健康对照组相比，全MWoA组、SDS（-）组和SDS（+）组的多个WM束均显示AD降低。此外，与SDS（-）组相比，SDS（+）组FA减少，MD和RD增加，AD保留，包括胼胝体的前束、体和压部，双侧上级纵束，右前放射冠和其他一些WM束，与抑郁症的先前发现相似。此外，SDS（+）组中上述部分WM束的平均FA和RD与SDS评分显著相关，包括胼胝体的前束和压部、右前放射冠和上级纵束。我们的研究结果表明，WM的完整性可能会受到抑郁症状（更敏感的RD）和偏头痛（更敏感的AD）。这些发现可能作为MWoA中抑郁严重程度的敏感生物标志物。版权所有© 2013约翰威利父子有限公司.
Previous studies have proven that migraine and depression are bidirectionally linked. However, few studies have investigated white matter (WM) integrity affected by depressive symptoms in patients suffering from migraine without aura (MWoA). Forty patients with MWoA were divided into two groups according to their self‐rating depression scale (SDS) score in the present study, including 20 in the SDS (+) (SDS > 49) group and 20 in the SDS (−) (SDS ≤ 49) group. Forty healthy participants were also recruited as the control group. Tract‐based spatial statistics analyses with multiple diffusion tensor imaging‐derived indices [fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD)] were employed collectively to investigate WM integrity between all patients with MWoA and all healthy controls, between each subgroup (SDS (−) group and SDS (+) group) and healthy controls, and between the SDS (−) and SDS (+) groups. Compared with healthy controls, decreased AD was shown in several WM tracts of the whole MWoA group, SDS (−) group and SDS (+) group. In addition, compared with the SDS (−) group, the SDS (+) group showed decreased FA and increased MD and RD, with conserved AD, including the genu, body and splenium of the corpus callosum, bilateral superior longitudinal fasciculi, the right anterior corona radiata and some other WM tracts, similar to previous findings in depression disorder. Furthermore, mean FA and RD in some of the above‐mentioned WM tracts in the SDS (+) group were correlated significantly with SDS scores, including the genu and splenium of the corpus callosum, the right anterior corona radiata and the superior longitudinal fasciculi. Our results suggest that WM integrity may be affected by both depression symptoms (more sensitive as RD) and migraine (more sensitive as AD). The findings may serve as a sensitive biomarker of depression severity in MWoA. Copyright © 2013 John Wiley & Sons, Ltd.