Effective thalamic deep brain stimulation for neuropathic tremor in a patient with severe demyelinating neuropathy
Effective thalamic deep brain stimulation for neuropathic tremor in a patient with severe demyelinating neuropathy
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DOI：
10.1136/jnnp.2008.145656
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发表时间：
2009-02-01
影响因子：
11
通讯作者：
Krueger, R.
中科院分区：
文献类型：
--
作者：
Breit, S.;Waechter, T.;Krueger, R.
周围神经病的姿势和动作震颤是Roussy-Levy综合征的特征。报道1例严重脱髓鞘神经病和致残神经病理性震颤患者，经脑深部刺激(DBS)成功治疗。发病年龄63岁，伴有感觉性症状和轻微的动作性震颤。在接下来的9年里，患者出现了严重的抗药性、姿势和动作性震颤，导致患者无法自我进食。在72岁时，患者接受了双侧丘脑腹侧中间核DBS治疗，有效地减少了30%的震颤。在一年的术后观察期内，刺激的临床益处保持稳定。
Postural and action tremor in peripheral neuropathy is characteristic of Roussy-Levy syndrome. A patient with a severe demyelinating neuropathy and disabling neuropathic tremor successfully treated by deep brain stimulation (DBS) is reported. Disease onset was at age 63 years with sensory symptoms and slight action tremor. Within the following 9 years a severe, drug resistant, postural and action tremor developed rendering the patient unable to feed himself. At age 72 years the patient was treated by bilateral DBS of the ventral intermediate thalamic nucleus, with a useful 30% reduction in tremor. The clinical benefit of the stimulation remained stable over a 1 year postoperative observation period.