Association of chronic hepatitis C with recurrent brief depression
Association of chronic hepatitis C with recurrent brief depression
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DOI：
10.1016/j.jad.2012.03.020
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发表时间：
2012-12-10
影响因子：
6.6
通讯作者：
Farci, Patrizia
中科院分区：
文献类型：
--
作者：
Carta, Mauro G.;Angst, Jules;Farci, Patrizia
背景：抑郁综合征，包括复发性短暂抑郁（RBD），经常被观察到与以免疫激活为特征的慢性疾病相关，如自身免疫性甲状腺炎或乳糜泻。然而，RBD与慢性丙型肝炎（CHC）的关系尚不清楚，慢性丙型肝炎是一种增加重度抑郁症发病率的疾病。方法：135例（男83例，女52例）连续未接受治疗的CHC患者。排除标准：既往ifn - α治疗，丙型肝炎病毒（HCV）和乙型肝炎病毒合并感染，人类免疫缺陷病毒（HIV）感染，药物或酒精滥用，或恶性肿瘤。对照：540名（332名男性，208名女性）无肝炎证据的受试者，随机从先前流行病学研究的数据库中提取。精神病诊断基于综合国际诊断访谈简化（CIDI-S），其中包含RBD的特定部分。结果：男性和女性CHC患者的RBD发生率（n=21, 15.5%）明显高于对照组（n=34, 6.3%） （OR=2.6， CI 95%从1.37到4.93）。结论：本研究首次提供了CHC与RBD之间存在关联的证据，该关联与ifn - α治疗无关，且不受药物或酒精滥用的影响。结果与在其他免疫激活条件下发现的结果相似。RBD可能是这种情况下情绪障碍的另一种表现。(C) 2012 Elsevier b.v.版权所有
Background: Depressive syndromes, including recurrent brief depression (RBD), have frequently been observed in association with chronic diseases characterized by immune activation, such as autoimmune thyroiditis or celiac disease. However, the association of RBD with chronic hepatitis C (CHC), a disease with an increased incidence of major depressive disorders, is unknown.Methods: Cases: 135 (83 males, 52 females) consecutive treatment-naive patients with CHC. Exclusion criteria: previous treatment with IFN-alpha, co-infection with hepatitis C virus (HCV) and hepatitis B virus, infection with human immunodeficiency virus (HIV), drug or alcohol abuse, or malignancy. Controls: 540 (332 males, 208 females) subjects without evidence of hepatitis, randomly extracted from the database of a previous epidemiological study. The psychiatric diagnosis was based on the Composite International Diagnostic Interview Simplified (CIDI-S), containing a specific section on RBD.Results: A significantly higher rate of RBD was observed among both male and female patients with CHC (n=21, 15.5%) as compared to controls (n=34, 6.3%) (OR=2.6, CI 95% from 1.37 to 4.93).Conclusion: The present study provides the first evidence of an association between CHC and RBD, independent of treatment with IFN-alpha and not influenced by substance or alcohol abuse. The results are similar to those found in other conditions with immune activation. RBD may be another expression of mood disorders in such conditions. (C) 2012 Elsevier B. V. All rights reserved.