XRCC3 and RAD51 expression are associated with clinical factors in breast cancer.
XRCC3 and RAD51 expression are associated with clinical factors in breast cancer.
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DOI：
10.1371/journal.pone.0072104
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Wang YJ
中科院分区：
文献类型：
--
作者：
Hu J;Wang N;Wang YJ
XRCC3和RAD51是同源重组修复途径中的两个重要成员。本研究旨在检测这两种分子在乳腺癌组织中的表达，并探讨其与临床病理因素的相关性。采用免疫组化法检测248例乳腺癌组织和78例癌旁组织中XRCC 3和RAD 51蛋白的表达。数据显示，XRCC3和RAD51的表达在乳腺癌中显著增加。XRCC3高表达与肿瘤大小、PR和HER2阳性相关，而RAD 51高表达与腋窝淋巴结转移、PR和HER2阳性相关。多因素分析结果显示，HER2、PR和RAD51与XRCC3有显著相关性。除XRCC3外，RAD51与腋淋巴结转移、PR均显著相关。XRCC3和RAD51与乳腺癌的临床病理因素密切相关，可能在乳腺癌的发生发展中起重要作用。
XRCC3 and RAD51 are two important members in homologous recombination repair pathway. This study was performed to detect the expressions of these two molecules in breast cancer and explore their correlations with clinicopathological factors. Immunohistochemistry was used to detect protein expressions of XRCC3 and RAD51 in 248 cases of breast cancer tissue and 78 cases of adjacent non-cancerous tissue. Data showed that expressions for both XRCC3 and RAD51 were significantly increased in breast cancer. High XRCC3 expression was associated with large tumor size and positive PR and HER2 status, while high RAD51 expression was associated with axillary lymph node metastasis and positive PR and HER2 status. The result of multivariate analysis demonstrated that HER2, PR and RAD51 were significantly association with XRCC3. And besides XRCC3, axillary lymph node metastasis and PR were significantly correlated with RAD51. XRCC3 and RAD51 were significantly associated with clinicopathological factors and they might play important roles in the development and progress of breast cancer.
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