ROLE OF AUDITORY CORTEX IN DISCRIMINATION OF CHANGES IN FREQUENCY
ROLE OF AUDITORY CORTEX IN DISCRIMINATION OF CHANGES IN FREQUENCY
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DOI：
10.1152/jn.1957.20.1.108
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发表时间：
1957-01-01
影响因子：
2.5
通讯作者：
NEFF, WD
中科院分区：
文献类型：
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作者：
BUTLER, RA;DIAMOND, IT;NEFF, WD
猫被训练通过对音调刺激频率的微小变化做出反应来避免电击。双侧消融后的听觉区I，II，和EP，和双侧消融后的躯体区II除了AI，AII，和EP，辨别频率变化的能力基本上是不受损害的。对习得的习惯发生了暂时的遗忘，但所有的动物都能够重新学习。对实验动物大脑的尸检显示，在所有听皮质切除的情况下，内侧膝状体主体部分的前2/3完全变性。由于消融扩大到包括通常定义的听觉皮层边界腹侧的颞叶和岛叶皮层，退化进一步延伸到内侧膝状体的后尖。在所有情况下，背后尖的一小部分保持完整。内侧膝状体大细胞区及丘脑其他核团如枕、外侧膝状体、N。后外侧核和后外侧核腹后肌内侧膝状体外的变性是皮质下通路或AI、AII和Ep区外皮质损伤的结果。
Cats were trained to avoid shock by responding to small changes in the frequency of a tonal stimulus. After bilateral ablation of auditory areas I, II, and Ep, and after bilateral ablation of somatic area II in addition to AI, AII, and Ep, ability to discriminate changes in frequency was essentially unimpaired. A temporary amnesia for the learned habit occurred but all animals were able to relearn. Postmortem examination of the brains of experimental animals revealed that in all cases of auditory cortex ablation, the anterior 2/3 of the principal part of the medial geniculate was completely degenerated. As the ablation was enlarged to include temporal and insular cortex ventral to the boundaries of the auditory cortex as usually defined, degeneration extended further into the posterior tip of the medial geniculate. In all cases, a small portion of the dorsal posterior tip remained intact. Retrograde degeneration also occurred in the magnocellular division of the medial geniculate and in other thalamic nuclei, such as the pulvinar, lateral geniculate, n. lateralis posterior and n. ventralis posterior. The degeneration outside of the medial geniculate was the result of damage to subcortical pathways or to cortex outside of areas AI, AII, and Ep.