Hardness Sensed by Skin Palpation in Legs with Lymphedema Is Predominantly Correlated with Dermal Thickening
Hardness Sensed by Skin Palpation in Legs with Lymphedema Is Predominantly Correlated with Dermal Thickening
复制标题
淋巴水肿腿部皮肤触诊感觉到的硬度主要与真皮增厚相关
DOI：
10.1089/lrb.2020.0133
复制
发表时间：
2021
影响因子：
1.4
通讯作者：
Hamano Kimikazu
中科院分区：
文献类型：
--
作者：
Suehiro Kotaro;Mizumoto Yukie;Morikage Noriyasu;Harada Takasuke;Samura Makoto;Nagase Takashi;Takeuchi Yuriko;Mizoguchi Takahiro;Suzuki Ryo;Kurazumi Hiroshi;Hamano Kimikazu
背景：我们的目的是澄清是否在皮肤和皮下组织的病理变化，水肿影响皮肤硬度感知触诊。方法和结果：在50例单侧下肢水肿（LE），大腿内侧下部和小腿内侧下部的皮肤硬度测定使用范围从1（最软）到7（最硬）触诊的基础上。然后，将皮肤硬度与从触诊部位获得的皮肤/皮下组织超声图像的测量值相关联。多因素Logistic回归分析显示，皮肤厚度是影响下肢与对侧无症状下肢皮肤硬度差异的显著因素，其中大腿（p< 0.05）和小腿（p< 0.01）的皮肤硬度差异显著。当大腿和小腿在LE单独研究，皮下回声（p< 0.05），表明皮下炎症/纤维化，和皮下厚度（p< 0.01）似乎也影响皮肤硬度，分别。此外，LE引起的皮下组织病理变化似乎对皮肤硬度有影响。临床试验注册号2020-150。
Background:We aimed to clarify whether pathological changes in skin and subcutaneous tissue with lymphedema affected the skin hardness sensed by palpation.Methods and Results:In 50 patients with unilateral legs with lymphedema (LE), the skin hardness of the lower inner thigh and lower inner calf was determined using a scale ranging from 1 (softest) to 7 (hardest) based on palpation. Then, the skin hardness was correlated with the measurements of skin/subcutaneous tissue ultrasonography images obtained from the palpated parts. Multivariate logistic regression analysis demonstrated that dermal thickness was a significant factor that affected the difference in skin hardness between the LE and the contralateral asymptomatic leg for both thigh (p< 0.05) and calf (p< 0.01). When the thigh and calf in the LE were individually studied, subcutaneous echogenicity (p< 0.05), indicating subcutaneous inflammation/fibrosis, and subcutaneous thickness (p< 0.01) also seemed to affect skin hardness, respectively.Conclusions:The skin hardness sensed in the LE seemed to be affected predominantly by dermal thickening. In addition, the pathological changes in the subcutaneous tissue caused by LE seemed to have an impact on skin hardness. Clinical Trial Registration number 2020–150.