Repetitive behavior profiles: Consistency across autism spectrum disorder cohorts and divergence from Prader-Willi syndrome.
Repetitive behavior profiles: Consistency across autism spectrum disorder cohorts and divergence from Prader-Willi syndrome.
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DOI：
10.1007/s11689-011-9094-3
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发表时间：
2011-12
影响因子：
4.9
通讯作者：
Kim, Soo-Jeong
中科院分区：
文献类型：
--
作者：
Flores, Cindi G.;Valcante, Gregory;Guter, Steve;Zaytoun, Annette;Wray, Emily;Bell, Lindsay;Jacob, Suma;Lewis, Mark H.;Driscoll, Daniel J.;Cook, Edwin H., Jr.;Kim, Soo-Jeong
限制性和重复性行为（RRB）是一组异质性的适应不良行为。RRB是自闭症谱系障碍（ASD）的关键诊断特征之一，在普拉德 - 威利综合征（PWS）中也常见。在这项研究中，我们使用修订版重复行为量表（RBS - R）对两个自闭症样本（伊利诺伊大学芝加哥分校[UIC]和佛罗里达大学[UF]）以及一个普拉德 - 威利综合征样本评估了RRB。我们比较了三个自闭症队列（UIC、UF以及来自Lam的一个自闭症样本，《修订版重复行为量表：独立验证及受试者变量的影响》，博士论文）和一个普拉德 - 威利综合征样本的RBS - R项目认可情况。我们还比较了UIC、UF和PWS样本之间的RBS - R分量表/总分均值；比较了合并的自闭症（UIC + UF）、PWS缺失和PWS双体组之间的情况；以及比较了合并的自闭症样本、社会交往问卷（SCQ）得分≥15的PWS亚组和SCQ得分<15的PWS亚组之间的情况。尽管具有高度异质性，但三个自闭症样本（UIC、UF和Lam的样本）在RBS - R认可情况上呈现出相似模式，并且UIC和UF样本之间的RBS - R平均得分没有差异。然而，与PWS样本相比，自闭症样本中RRB更为明显，并且SCQ得分≥15的PWS亚组与SCQ得分<15的PWS亚组相比也是如此。研究的局限性包括样本量小、参与者年龄范围广以及未控制潜在的协变量。鉴于SCQ得分≥15的PWS亚组中RRB较高，未来需要使用更大样本进行重复研究，并进一步探究自闭症和RRB现象重叠的遗传基础。
Restricted and repetitive behavior (RRB) is a group of heterogeneous maladaptive behaviors. RRB is one of the key diagnostic features of autism spectrum disorders (ASDs) and also commonly observed in Prader–Willi syndrome (PWS). In this study, we assessed RRB using the Repetitive Behavior Scale-Revised (RBS-R) in two ASD samples (University of Illinois at Chicago [UIC] and University of Florida [UF]) and one PWS sample. We compared the RBS-R item endorsements across three ASD cohorts (UIC, UF and an ASD sample from Lam, The Repetitive Behavior Scale-Revised: independent validation and the effect of subject variables, PhD thesis,), and a PWS sample. We also compared the mean RBS-R subscale/sum scores across the UIC, UF and PWS samples; across the combined ASD (UIC + UF), PWS-deletion and PWS-disomy groups; and across the combined ASD sample, PWS subgroup with a Social Communication Questionnaire (SCQ) score ≥15, and PWS subgroup with a SCQ score <15. Despite the highly heterogeneous nature, the three ASD samples (UIC, UF and Lam’s) showed a similar pattern of the RBS-R endorsements, and the mean RBS-R scores were not different between the UIC and UF samples. However, higher RRB was noted in the ASD sample compared with the PWS sample, as well as in the PWS subgroup with a SCQ score ≥15 compared with the PWS subgroup with a SCQ score <15. Study limitations include a small sample size, a wide age range of our participants, and not controlling for potential covariates. A future replication study using a larger sample and further investigation into the genetic bases of overlapping ASD and RRB phenomenology are needed, given the higher RRB in the PWS subgroup with a SCQ score ≥15.
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影响因子：
3.5
作者：
Boyar, FZ;Whitney, MM;Driscoll, DJ
通讯作者：
Driscoll, DJ
影响因子：
9.8
作者：
Browne, CE;Dennis, NR;Barber, JCK
通讯作者：
Barber, JCK
DOI：
10.1111/j.1469-7610.2007.01762.x
发表时间：
2007-09-01
影响因子：
7.6
作者：
Corsello, Christina;Hus, Vanessa;Lord, Catherine
通讯作者：
Lord, Catherine
DOI：
10.1111/1469-7610.00114
发表时间：
2002-10-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
Bishop, DVM;Norbury, CF
通讯作者：
Norbury, CF
影响因子：
0.9
作者：
Bolton, PF;Veltman, MWM;Brown, J
通讯作者：
Brown, J