A sticky situation: untangling the transcriptional network controlling biofilm development in Candida albicans.
A sticky situation: untangling the transcriptional network controlling biofilm development in Candida albicans.
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DOI：
10.4161/trns.22281
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Nobile CJ
中科院分区：
文献类型：
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作者：
Fox EP;Nobile CJ
白色念珠菌是人类微生物组的寄生微生物;它也是人类最普遍的真菌病原体。C.白色念珠菌是其倾向于形成生物膜-弹性的、表面相关的细胞群落的直接结果，其中单个细胞获得与悬浮培养物中观察到的特性不同的专门特性。我们最近确定了在C.白色念珠菌这些结果为理解生物膜是如何形成的以及一旦形成，生物膜的特殊性质是如何阐述的奠定了基础。这些信息将为更详细地了解生物膜提供新的见解，并可能导致未来预防和治疗生物膜感染的改进。
Candida albicans is a commensal microorganism of the human microbiome; it is also the most prevalent fungal pathogen of humans. Many infections caused by C. albicans are a direct consequence of its proclivity to form biofilms—resilient, surface-associated communities of cells where individual cells acquire specialized properties that are distinct from those observed in suspension cultures. We recently identified the transcriptional network that orchestrates the formation of biofilms in C. albicans. These results set the stage for understanding how biofilms are formed and, once formed, how the specialized properties of biofilms are elaborated. This information will provide new insight for understanding biofilms in more detail and may lead to improvements in preventing and treating biofilm-based infections in the future.