Histamine H(4) receptor antagonists ineffective against itch and skin inflammation in atopic dermatitis mouse model.
Histamine H(4) receptor antagonists ineffective against itch and skin inflammation in atopic dermatitis mouse model.
复制标题
组胺 H(4) 受体拮抗剂对特应性皮炎小鼠模型的瘙痒和皮肤炎症无效。
DOI：
10.1038/jid.2013.351
复制
发表时间：
2014
影响因子：
6.5
通讯作者：
Takamori K
中科院分区：
文献类型：
--
作者：
Kamo A;Negi O;Tengara S;Kamata Y;Noguchi A;Ogawa H;Tominaga M;Takamori K
组胺是人类最广为人知的瘙痒原，也是最常用的实验性瘙痒物质。与正常皮肤相比，特应性皮炎(AD)患者皮损皮肤的瘙痒反应增加(Ikoma等人，2006年)。然而，组胺H1受体(H1R)拮抗剂往往无法缓解AD患者的瘙痒，对患有肾脏和肝脏疾病等全身疾病的患者也是如此。在瘙痒患者中，不同类型的高效H1R拮抗剂缺乏改善表明其他系统参与其中(Ikoma等人，2006；Ständer和Weisshaar，2012)。组胺H4受体(H4R)参与组胺诱导的瘙痒的动物模型已有报道(Dunford等人，2007年；瑟蒙德等人，2008年)，但H4R拮抗剂对AD患者H1R拮抗性瘙痒的治疗效果知之甚少。因此，我们研究了H4R拮抗剂对AD的瘙痒和皮肤炎的治疗效果，使用了NC/NGA小鼠，这是一种先前已经描述过的AD小鼠模型
Histamine is the best known pruritogen in humans and the most commonly used experimental itch-causing substance. It induces increased itch responses in the lesional skin of atopic dermatitis (AD) patients compared with normal skin (Ikoma et al., 2006). However, histamine H1 receptor (H1R) antagonists frequently fail to relieve the itch in AD patients as well as it does in patients with systemic diseases such as kidney and liver diseases. The lack of amelioration by high-potency H1R antagonists of different types in patients with itch suggests that other systems are involved (Ikoma et al., 2006; Ständer and Weisshaar, 2012). Involvement of histamine H4 receptor (H4R) in histamine-evoked itch in animal models has been reported (Dunford et al., 2007; Thurmond et al., 2008).However, the therapeutic efficacy of H4R antagonists on the H1R antagonistresistant itch in AD is poorly understood. We therefore examined the therapeutic effects of H4R antagonists on itch and skin inflammation in AD using NC/Nga mice, a mouse model of AD that has been previously described