The effect of epitope-based ligation of ICAM-1 on survival and retransplantation of pig islets in nonhuman primates
The effect of epitope-based ligation of ICAM-1 on survival and retransplantation of pig islets in nonhuman primates
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DOI：
10.1111/xen.12362
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发表时间：
2018-01-01
影响因子：
3.9
通讯作者：
Park, Seong Hoe
中科院分区：
文献类型：
--
作者：
Lee, Jae-Il;Kim, Jiyeon;Park, Seong Hoe
背景异种猪胰岛移植是替代同种异体移植的一种有前途的方法。然而，猪和灵长类动物之间广泛的免疫屏障限制了移植物的长期存活。MD-3是一种识别人ICAM-1特定表位的新型单克隆抗体（mAb），可通过阻止树突状细胞成熟而使T细胞对异种移植物耐受。我们报告的长期生存的成年野生型猪胰岛和成功的再次移植在非人灵长类动物使用的协议，包括诱导与MD-3单克隆抗体和维护与抗CD 154单克隆抗体和sirolimus.MethodsEleven恒河猴被分配到三个组。第1组（n=4）包括MD-3诱导治疗，短期（
BackgroundPig islet xenotransplantation is a promising alternative to allogeneic transplantation. However, the wide immunologic barrier between pigs and primates limits the long-term survival of the graft. MD-3, a novel monoclonal antibody (mAb) that recognizes a particular epitope of human ICAM-1, can render T cells tolerant to a xenograft by arresting dendritic cell maturation. We report the long-term survival of adult wild-type pig islets and successful retransplantation in nonhuman primates using a protocol comprising induction with MD-3 mAb and maintenance with anti-CD154 mAb and sirolimus.MethodsEleven rhesus monkeys were assigned to three groups. Group 1 (n=4) involved treatment with MD-3 induction, short-term (