Comorbidity, socioeconomic status and multiple sclerosis
Comorbidity, socioeconomic status and multiple sclerosis
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DOI：
10.1177/1352458508092263
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发表时间：
2008-09-01
影响因子：
5.8
通讯作者：
Vollmer, T.
中科院分区：
文献类型：
--
作者：
Marrie, R. A.;Horwitz, R.;Vollmer, T.
目的多发性硬化（MS）是一种发病率较高的疾病。合并症对MS的影响尚不清楚，但合并症可能解释一些不可预测的进展。合并症在一般人群中很常见，并与不良健康结果相关。为了开始了解合并症对MS的影响，我们需要了解MS患者合并症的广度、类型和频率。使用北美多发性硬化症研究委员会（NARCOMS）登记处，我们的目的是描述合并症及其人口统计学预测MS。方法在2006年10月，我们询问NARCOMS参与者的身体合并症。符合纳入标准的16,141名参与者，8983（55.7%）responded.Results合并症是相对常见的，如果我们考虑的条件是很可能是准确的自我报告，然后3280（36.7%）报告至少有一个物理合并症。最常报告的合并症为高胆固醇血症（37%）、高血压（30%）和关节炎（16%）。与合并症风险相关的是男性[女性vs.男性，比值比（OR）0.77; 0.69-0.87];年龄（年龄>60岁vs.
Objective Multiple sclerosis (MS) is associated with substantial morbidity. The impact of comorbidity on MS is unknown, but comorbidity may explain some of the unpredictable progression. Comorbidity is common in the general population, and is associated with adverse health outcomes. To begin understanding the impact of comorbidity on MS, we need to know the breadth, type, and frequencies of comorbidities among MS patients. Using the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry, we aimed to describe comorbidities and their demographic predictors in MS.Methods In October 2006, we queried NARCOMS participants regarding physical comorbidities. Of 16,141 participants meeting the inclusion criteria, 8983 (55.7%) responded.Results Comorbidity was relatively common; if we considered conditions which are very likely to be accurately self-reported, then 3280 (36.7%) reported at least one physical comorbidity. The most frequently reported comorbidities were hypercholesterolemia (37%), hypertension (30%), and arthritis (16%). Associated with the risk of comorbidity were being male [ females vs. males, odds ratio (OR) 0.77; 0.69-0.87]; age (age >60 years vs. age