A comparison of homologous recombination rates in bacteria and archaea
A comparison of homologous recombination rates in bacteria and archaea
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DOI：
10.1038/ismej.2008.93
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发表时间：
2009-02-01
期刊：
影响因子：
11
通讯作者：
Didelot, Xavier
中科院分区：
文献类型：
--
作者：
Vos, Michiel;Didelot, Xavier
在检查细菌种群遗传多样性的研究中，检测同源重组的特征是一种标准做法。虽然已经出现同源重组率可以在物种之间有很大的差异，但由于所使用的估计方法的多样性，很难比较不同研究的结果。在这里，使用ClonalFrame方法分析了来自各种细菌和古细菌的多位点序列分型（MLST）数据集。这使得物种之间的直接比较，并允许第一次探索的问题，是否同源重组率的主要决定因素是遗传或生态。
It is a standard practice to test for the signature of homologous recombination in studies examining the genetic diversity of bacterial populations. Although it has emerged that homologous recombination rates can vary widely between species, comparing the results from different studies is made difficult by the diversity of estimation methods used. Here, Multi Locus Sequence Typing (MLST) datasets from a wide variety of bacteria and archaea are analyzed using the ClonalFrame method. This enables a direct comparison between species and allows for a first exploration of the question whether phylogeny or ecology is the primary determinant of homologous recombination rate.