Choleretic effects of curcuminoids on an acute cyclosporin-induced cholestasis in the rat
Choleretic effects of curcuminoids on an acute cyclosporin-induced cholestasis in the rat
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DOI：
10.1055/s-1999-14033
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发表时间：
1999-10-01
期刊：
影响因子：
2.7
通讯作者：
H채nsel, W
中科院分区：
文献类型：
--
作者：
Deters, M;Siegers, C;H채nsel, W
先前的研究表明，姜黄素可以从不同种类的姜黄中提取，可以刺激大鼠的胆汁流动，而双去甲氧基姜黄素主要存在于姜黄根状茎中，被认为可以抑制胆汁流动。为了重新评价这一观察结果，我们在大鼠胆管模型中研究了两种姜黄素在180 min时间内对胆汁流动、胆汁酸浓度和排泄的影响。此外，我们测试了两种姜黄素降低环孢素诱导的胆汁淤积的能力。静脉注射姜黄素25 mg/kg和双去甲氧基姜黄素30 min后，胆流量分别从500 μ l/kg/15 min（100%）提高到180%和220%。双去甲氧基姜黄素的降胆作用持续时间较姜黄素长。静脉注射环孢素30 mg/kg后，胆汁流量、胆汁酸浓度（15 mmol/l）和排泄量（12.5 mu mol/kg/15 min）降至初始值的40%，姜黄素和双去甲氧基姜黄素分别使胆汁流量瞬时增加至初始值的100%和125%。然而，只有双去甲氧基姜黄素在统计学上显著减弱环孢素诱导的胆汁酸排泄减少。我们的结论是：姜黄素对治疗环孢素诱导的胆汁淤积的有益性质仍有待证实。
Former studies have shown that curcumin, which can be extracted from different Curcuma species, is able to stimulate bile flow in rats, whereas bisdemethoxycurcumin, which is mainly found in rhizomes of Curcumca longo, is believed to inhibit bile flow To reevaluate this observation we investigated the influence of both curcuminoids on bile flow, bile acid concentration and excretion over a time period of 180 min in the bile fistula model in rats. Furthermore, we tested the ability of both curcuminoids to reduce cyclosporin-induced cholestasis. 30 min after intravenous injection of 25 mg/kg of curcumin and bisdemethoxycurcumin bile flow was enhanced from 500 mu l/kg/15 min (100 %) to 180 % and to 220 %, respectively. The choleretic effect of bisdemethoxycurcumin lasted longer than that of curcumin. Following intravenous injection of 30 mg/kg of cyclosporin, which reduced bile flow, bile acid concentration (15 mmol/l) and excretion (12.5 mu mol/kg/15 min) to 40 % of the initial value, administration of curcumin and bisdemethoxycurcumin transiently increased bile flow to 100% and to 125% of the starting value, respectively. However, only bisdemethoxycurcumin statistically significantly attenuated cyclosporin-induced reduction of bile acid excretion. We conclude that: the beneficial properties of curcuminoids for the therapy of cyclosporin-induced cholestasis still remain to be proven.