The role of the insulin-like growth factor 1 (IGF-1) in skeletal muscle physiology.
The role of the insulin-like growth factor 1 (IGF-1) in skeletal muscle physiology.
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发表时间：
2007
期刊：
影响因子：
2.3
通讯作者：
A. Philippou;M. Maridaki;A. Halapas;M. Koutsilieris
中科院分区：
文献类型：
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作者：
A. Philippou;M. Maridaki;A. Halapas;M. Koutsilieris
人胰岛素样生长因子-1 (IGF-1) 基因通过多个转录起始位点、选择性剪接和不同的聚腺苷酸化信号的组合产生多个异质 mRNA 转录本。这些 IGF-1 mRNA 转录物编码 IGF-1 前体肽的不同亚型（IGF-1Ea、IGF-1Eb 和 IGF-1Ec 或人类骨骼肌中的 MGF），这些亚型也经历翻译后修饰。人们越来越关注 IGF-1 同种型在机械超负荷和损伤后调节肌纤维再生和肥大中的差异表达和影响。骨骼肌中局部表达、负荷或损伤敏感的 IGF-1 同工型的鉴定是 IGF-1 自分泌/旁分泌作用中最有吸引力的进展之一。本综述讨论了这样的概念：细胞增殖和分化的竞争过程以及肌肉修复或肥大适应所需的蛋白质合成增加是由 IGF-1 亚型的差异表达和不同作用调节的。
The human insulin-like growth factor-1 (IGF-1) gene gives rise to multiple, heterogeneous mRNA transcripts through a combination of multiple transcription initiation sites, alternative splicing and different polyadenylation signals. These IGF-1 mRNA transcripts code different isoforms of the precursor peptide of IGF-1 (IGF-1Ea, IGF-1Eb and IGF-1Ec or MGF in human skeletal muscle), which also undergo post-translational modification. There is increasing interest in differential expression and implication of IGF-1 isoforms in the regulation of muscle fiber regeneration and hypertrophy following mechanical overloading and damage. The identification of a locally expressed, loading- or damage-sensitive IGF-1 isoform in skeletal muscle was one of the most attractive developments in the context of the autocrine/paracrine actions of IGF-1. The concept that the competing processes of cellular proliferation and differentiation and the increased protein synthesis required for muscle repair or hypertrophic adaptation are regulated by a differential expression and by distinct roles of IGF-1 isoforms is discussed in the present review.