The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice
The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice
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DOI：
10.1007/s10522-007-9100-z
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发表时间：
2007-10-01
期刊：
影响因子：
4.5
通讯作者：
Yokozawa, Takako
中科院分区：
文献类型：
--
作者：
Kitani, Kenichi;Osawa, Toshihiko;Yokozawa, Takako
研究了两种不同的抗氧化剂四氢姜黄素（TC）和绿色茶多酚（PP）对雄性C57 BL/6小鼠存活率的影响。在13个月大时开始接受含TC（0.2%）饮食的小鼠的平均寿命（天，平均值+/- SD）显著长于对照小鼠（797.6 +/- 151.2 vs.882 +/- 154.6，均为n = 50，对照组vs TC治疗组，加11.7%，P < 0.01）。TC治疗组小鼠的10%最长存活率也显著更高（加6.5%，P < 0.01）。相比之下，在出生后19个月开始接受TC的小鼠中，无论是平均寿命还是10%的最长生存期，都与对照小鼠没有显著差异。在接受含有PP（80 mg/l）的水的小鼠中，平均寿命也显著长于对照小鼠（801 +/- 121.5 vs. 852.7 +/- 88.2，加6.4%，P < 0.05），尽管10%最长存活率与对照小鼠无显著差异（P > 0.05）。在治疗的前六个月，TC（而非PP）喂养的小鼠的体重略微（2-4%）但显著（P < 0.05）低于对照小鼠中相应年龄的值。此后，对照组和TC饲喂组动物之间的平均体重差异完全消失。虽然不排除由于TC喂养（怀疑是由于体重差异）导致的食物摄入量意外轻微减少的额外贡献，但我们认为营养抗氧化剂（如TC和PP）的喂养可能有可能有益地改变动物的寿命。
The effect of feeding of two different antioxidants, tetrahydrocurcumin (TC) and green tea polyphenols (PPs) on the survival of male C57BL/6 mice was examined. Mice that started to receive diets containing TC (0.2%) at the age of 13 months had significantly longer average life spans (days, mean +/- SD) than control mice (797.6 +/- 151.2 vs.882 +/- 154.6, both n = 50, controls vs. TC treated, plus 11.7%, P < 0.01). The 10% longest survival was also significantly greater in TC-treated mice (plus 6.5%, P < 0.01). In contrast, in mice that started to receive TC in their 19th month of life, no significant difference from the control mice was found for either the average life span or the 10% longest survival. In mice that received water containing PPs (80 mg/l), the average life span was also significantly longer than in the control mice (801 +/- 121.5 vs. 852.7 +/- 88.2, plus 6.4%, P < 0.05), although the 10% longest survival was not significantly different from that in the control mice (P > 0.05). The body weights of the TC (but not PP) fed mice, were slightly (2-4%) but significantly (P < 0.05) lower than the values for the corresponding ages in the control mice in the first six months of treatment. Thereafter, the difference in average body weight between the control and the TC-fed animals was totally lost. Although an additional contribution of an unintended slight decrease in food intake due to TC feeding (suspected due to the difference in body weight) is not excluded, we suggest that the feeding of nutritional antioxidants such as TC and PPs may have the potential to beneficially modify the life spans of animals.