The association between hypertension and depression and anxiety disorders: results from a nationally-representative sample of South African adults.
The association between hypertension and depression and anxiety disorders: results from a nationally-representative sample of South African adults.
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DOI：
10.1371/journal.pone.0005552
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Myer L
中科院分区：
文献类型：
--
作者：
Grimsrud A;Stein DJ;Seedat S;Williams D;Myer L
越来越多的证据表明，高血压和精神疾病之间存在高水平的共病，但来自低收入和中等收入国家的数据很少。我们在南非调查了高血压与抑郁和焦虑之间的关系。数据来自全国代表性的成人调查（n = 4351）。 复合国际诊断访谈被用来衡量DSM-IV精神障碍在过去的12个月。自我报告的高血压和焦虑症，抑郁症和共病的焦虑抑郁症之间的关系进行了评估后，调整参与者的特征，包括创伤和其他慢性身体状况的经验。总体而言，16.7%的人报告了既往高血压的医学诊断，8.1%和4.9%的人分别被发现患有12个月的焦虑或抑郁症。在校正分析中，高血压诊断与12个月焦虑障碍相关[比值比（OR）= 1.55，95%置信区间（CI）= 1.10-2.18]，但与12个月抑郁障碍或12个月焦虑抑郁共病无关。 在没有其他慢性身体状况的情况下，高血压与任何12个月的心理健康结果无关（p值均<0.05），而被诊断患有高血压和另一种慢性身体状况与12个月的焦虑障碍相关（OR = 2.25，95%CI = 1.46-3.45），但与12个月的抑郁障碍或焦虑抑郁共病无关。 这是第一次基于人口的估计，以证明撒哈拉以南非洲高血压和精神障碍之间的联系。创伤性生活事件在高血压病因学中的作用以及高血压与精神障碍之间联系的时间性尚需进一步研究。
Growing evidence suggests high levels of comorbidity between hypertension and mental illness but there are few data from low- and middle-income countries. We examined the association between hypertension and depression and anxiety in South Africa. Data come from a nationally-representative survey of adults (n = 4351). The Composite International Diagnostic Interview was used to measure DSM-IV mental disorders during the previous 12-months. The relationships between self-reported hypertension and anxiety disorders, depressive disorders and comorbid anxiety-depression were assessed after adjustment for participant characteristics including experience of trauma and other chronic physical conditions. Overall 16.7% reported a previous medical diagnosis of hypertension, and 8.1% and 4.9% were found to have a 12-month anxiety or depressive disorder, respectively. In adjusted analyses, hypertension diagnosis was associated with 12-month anxiety disorders [Odds ratio (OR) = 1.55, 95% Confidence interval (CI) = 1.10–2.18] but not 12-month depressive disorders or 12-month comorbid anxiety-depression. Hypertension in the absence of other chronic physical conditions was not associated with any of the 12-month mental health outcomes (p-values all <0.05), while being diagnosed with both hypertension and another chronic physical condition were associated with 12-month anxiety disorders (OR = 2.25, 95% CI = 1.46–3.45), but not 12-month depressive disorders or comorbid anxiety-depression. These are the first population-based estimates to demonstrate an association between hypertension and mental disorders in sub-Saharan Africa. Further investigation is needed into role of traumatic life events in the aetiology of hypertension as well as the temporality of the association between hypertension and mental disorders.
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影响因子：
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作者：
Davidson, K;Jonas, BS;Markovitz, JH
通讯作者：
Markovitz, JH
影响因子：
4.7
作者：
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作者：
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通讯作者：
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