Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer
Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer
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采用新型光敏剂尾孢菌素封装的多功能共聚物进行靶向光动力治疗
DOI：
10.1016/j.colsurfa.2019.124136
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发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
Hu Jing
中科院分区：
文献类型：
--
作者：
Ye Zhou;Hua Dong;Rao Yijian;Bai Shuo;Seeberger Peter H.;Yin Jian;Hu Jing
Photoactivated perylenequinones are photosensitizers that transfer into reactive oxygen species with light energy for photodynamic therapy (PDT). Novel photoactivated perylenequinones photosensitizers are of current interest for application in PDT. Cercosporin, a new photoactivated perylenequinone photosensitizer, was encapsulated into multifunctional copolymer for targeting hepatocellular carcinoma cells to give enhanced PDT efficiency. The cercosporin encapsulated multifunctional copolymer exhibited higher targeting ability and better PDT efficiency to HepG2 cells compared with non-targeting copolymer system. Z-stack technique was used to monitor the cytoplasm distribution of cercosporin. The multifunctional copolymer can release cercosporin only in acidic tumor microenvironment to induce a PDT effect and realize the tracking ability thanks to covalent binding with rhodamine B. The cercosporin encapsulated multifunctional copolymer holds great potential in PDT for cancer treatment.
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影响因子：
15
作者：
Srinivasachari, Sathya;Fichter, Katye M.;Reineke, Theresa M.
通讯作者：
Reineke, Theresa M.
新型荧光素和罗丹明 B 化学传感器的合成和评估，用于比其他氨基酸高灵敏度和选择性检测半胱氨酸及其在活细胞成像中的应用
影响因子：
8.4
作者：
Chen Hailang;Zhou Baojing;Ye Renlong;Zhu Jing;Bao Xiaofeng
通讯作者：
Bao Xiaofeng
DOI：
10.1073/pnas.89.20.9588
发表时间：
1992-10-15
影响因子：
11.1
作者：
DAUB, ME;LEISMAN, GB;BOWDEN, EF
通讯作者：
BOWDEN, EF
影响因子：
15
作者：
KUYAMA, S;TAMURA, T
通讯作者：
TAMURA, T
影响因子：
3.3
作者：
A. Vandenbogaerde;E. Delaey;A. Vantieghem;B. Himpens;W. Merlevede;Peter A. Witte
通讯作者：
A. Vandenbogaerde;E. Delaey;A. Vantieghem;B. Himpens;W. Merlevede;Peter A. Witte