A prospective study of breast size and premenopausal breast cancer incidence
A prospective study of breast size and premenopausal breast cancer incidence
复制标题
DOI：
10.1002/ijc.21588
复制
发表时间：
2006-04-15
影响因子：
6.4
通讯作者：
Michels, KB
中科院分区：
文献类型：
--
作者：
Kusano, AS;Trichopoulos, D;Michels, KB
关于乳腺大小（乳腺肿块的代表）与乳腺癌风险之间关系的研究给出了模棱两可的结果。大多数是病例对照研究，统计效力有限。我们对参加护士健康研究II的绝经前妇女进行了一项前瞻性分析，以自我报告的胸罩罩杯尺寸测量乳房大小与乳腺癌风险之间的关系。1993年对89268名29-47岁的绝经前女性进行了20岁时胸罩罩杯大小的评估。随后对浸润性乳腺癌的病例进行了评估，直至2001年。采用Cox比例风险模型对乳腺癌的潜在混杂因素和危险因素进行校正，计算风险比（hr）和95%置信区间（ci）。在622,732人年的随访中，803名绝经前妇女被新诊断为浸润性乳腺癌。对于BMI低于25 kg/m(2)的女性，罩杯为“D或更大”的女性患乳腺癌的几率明显高于罩杯为“a或更小”的女性（协变量调整后的HR = 1.80; 95% CI 1.13-2.88； p趋势= 0.01）。BMI大于等于25kg /m2的女性没有明显的相关性。以18岁时的BMI （21 kg/m(2)）为截断点进行分层，得出了类似的结果。年轻时较大的罩杯与绝经前乳腺癌的高发病率相关，尽管这种关联仅限于较瘦的女性。(c) 2005 Wiley-Liss, Inc。
Studies of the association between breast size, as a proxy for mammary gland mass, and breast cancer risk have given equivocal results. Most have been case-control studies with limited statistical power. We conducted a prospective analysis of the relation between breast size as measured by self-reported bra cup size and breast cancer risk among premenopausal women enrolled in the Nurses' Health Study II. Bra cup size at age 20 was assessed among 89,268 premenopausal women aged 29-47 in 1993. Subsequent incident cases of invasive breast cancer were assessed until 2001. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with a Cox proportional hazards model adjusting for potential confounders and risk factors for breast cancer. During 622,732 person-years of follow-up, 803 premenopausal women were newly diagnosed with invasive breast cancer. For women with a BMI below 25 kg/m(2), those with a bra cup size of "D or larger" had a significantly higher incidence of breast cancer than women who reported "A or smaller" (covariate adjusted HR = 1.80; 95% CI 1.13-2.88; P-trend = 0.01). There was no significant association among women with a BMI of 25 kg/m2 or higher. Stratifying by BMI at age 18 at a cutoff point of 21 kg/m(2) gave similar results. Larger bra cup size at a young age is associated with a higher incidence of premenopausal breast cancer, though this association is limited to leaner women. (c) 2005 Wiley-Liss, Inc.