Self-Reported Hearing Loss and Longitudinal Cognitive Function in a Cohort Enriched with Risk for Alzheimer's Disease.
Self-Reported Hearing Loss and Longitudinal Cognitive Function in a Cohort Enriched with Risk for Alzheimer's Disease.
复制标题
在富含阿尔茨海默氏病风险的队列中，自我报告的听力损失和纵向认知功能。
DOI：
10.3233/jad-200701
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Litovsky RY
中科院分区：
文献类型：
--
作者：
Fields TN;Mueller KD;Koscik RL;Johnson SC;Okonkwo OC;Litovsky RY
越来越多的证据表明听力损失是轻度认知障碍和痴呆症的危险因素，但很少有研究探讨其与亚临床认知结果的关系。研究自我报告的听力损失对临床未受损的中晚期成年人的纵向认知功能的影响。纳入了来自威斯康星州阿尔茨海默病预防登记处（WRAP）的579名参与者。通过自我报告的诊断听力损失史确定听力状态。每个自我报告听力损失的参与者与两个从未报告听力损失的参与者使用最近邻匹配进行年龄和性别匹配。线性混合效应模型被用来检查自我报告的听力损失和年龄相关的认知轨迹与性别，识字率和种族，个人水平的随机截距和年龄相关的斜率的协变量之间的关联。认知结果包括速度和灵活性，视觉空间记忆和语言流畅性的措施。与从未报告听力损失的参与者相比，自我报告听力损失的参与者在速度和灵活性因子评分以及心理速度和执行功能的单一测试中表现出显着较差的表现。自我报告的听力损失与视觉空间记忆或语言流畅性之间没有关联。纵向上，自我报告的听力损失与速度和灵活性的下降速度较慢相关，并且任何其他认知测量的下降速度没有差异。自我报告的听力损失与较差的速度和灵活性有关，但与研究的任何领域的加速下降无关，与以前的研究结果相反。进一步的研究，包括行为听觉措施，在这个队列将澄清这些发现的鲁棒性。
Growing evidence suggests hearing loss is a risk factor for mild cognitive impairment and dementia, but few studies have examined its relationship to sub-clinical cognitive outcomes. To investigate the effect of self-reported hearing loss on longitudinal cognitive function in a risk-enriched cohort of clinically-unimpaired, late middle-aged adults. 579 participants from the Wisconsin Registry for Alzheimer’s Prevention (WRAP) were included. Hearing status was determined via self-reported history of diagnosed hearing loss. Each participant with self-reported hearing loss was age- and sex-matched to two participants who never reported hearing loss using nearest-neighbor matching. Linear mixed-effects models were used to examine associations between self-reported hearing loss and age-related cognitive trajectories with covariates of sex, literacy, and ethnicity, person-level random intercepts and age-related slopes. Cognitive outcomes encompassed measures of speed and flexibility, visuospatial memory, and verbal fluency. Participants with self-reported hearing loss exhibited significantly poorer performance on a speed and flexibility factor score and single test of psychomotor speed and executive function, relative to participants who never reported hearing loss. There was no association between self-reported hearing loss and visuospatial memory or verbal fluency. Longitudinally, self-reported hearing loss was associated with less rapid decline in speed and flexibility and no difference in rate of decline for any other cognitive measure. Self-reported hearing loss was associated with poorer speed and flexibility but not with accelerated decline in any domain studied, contrary to previous findings. Further studies involving behavioral auditory measures in this cohort would clarify the robustness of these findings.