MORPHOGENESIS OF THE POLARIZED EPITHELIAL-CELL PHENOTYPE
MORPHOGENESIS OF THE POLARIZED EPITHELIAL-CELL PHENOTYPE
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DOI：
10.1126/science.2672330
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发表时间：
1989-08-18
期刊：
影响因子：
56.9
通讯作者：
NELSON, WJ
中科院分区：
文献类型：
--
作者：
RODRIGUEZBOULAN, E;NELSON, WJ
极化上皮细胞在哺乳动物各种组织和器官的个体发育和功能中起着重要作用。一片极化上皮细胞（滋养外胚层）的形态发生是早期胚胎发育中细胞分化的第一个明显标志。在成人中，极化上皮细胞排列在所有体腔中，并出现在执行吸收和分泌的专门矢量运输功能的组织中。这种表型的产生是一个多阶段的过程，需要细胞外的线索和重组的蛋白质在细胞质和质膜上;一旦建立，表型是由特定的蛋白质和脂质的分离和保留在不同的顶端和基底侧质膜域保持。
Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs in mammals. The morphogenesis of a sheet of polarized epithelial cells (the trophectoderm) is the first overt sign of cellular differentiation in early embryonic development. In the adult, polarized epithelial cells line all body cavities and occur in tissues that carry out specialized vectorial transport functions of absorption and secretion. The generation of this phenotype is a multistage process requiring extracellular cues and the reorganization of proteins in the cytoplasm and on the plasma membrane; once established, the phenotype is maintained by the segregation and retention of specific proteins and lipids in distinct apical and basal-lateral plasma membrane domains.