A QUANTITATIVE DESCRIPTION OF MEMBRANE CURRENT AND ITS APPLICATION TO CONDUCTION AND EXCITATION IN NERVE
A QUANTITATIVE DESCRIPTION OF MEMBRANE CURRENT AND ITS APPLICATION TO CONDUCTION AND EXCITATION IN NERVE
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DOI：
10.1113/jphysiol.1952.sp004764
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发表时间：
1952-01-01
影响因子：
5.5
通讯作者：
HUXLEY, AF
中科院分区：
文献类型：
--
作者：
HODGKIN, AL;HUXLEY, AF
一系列关于电流流过鱿鱼巨大神经纤维表面膜的论文（同上，第109卷，第106页。240-249; vol. 116，pp. #24506;的结束。它讨论了前面的论文的结果，把它们转化为数学形式，并显示了它们如何可以解释传导和激励的定量条款。先前获得的电压钳数据被用来找到方程描述的Na和K电导的变化与膜电位的改变。确定了方程中的参数。通过拟合solns。到EXPTL。不同膜电位下Na和K电导率与时间的关系曲线。一个孤立的巨大轴突对电刺激的反应可能是由于膜电位变化引起的Na和K渗透性的可逆性改变。
A series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fiber of the squid (ibid., vol. 109, pp. 240-249; vol. 116, pp. 424-506) is concluded. It discusses the results of the preceding papers, puts them into mathematical form, and shows how they can account for conduction and excitation in quantitative terms. The voltage clamp data obtained previously are used to find equations which describe the changes in Na and K conductance associated with an alteration of membrane potential. The parameters in these equations were detd. by fitting solns. to the exptl. curves relating Na and K conductance to time at various membrane potentials. The responses of an isolated giant axon to electrical stimuli are probably due to reversible alterations in Na and K permeability arising from changes in membrane potential.